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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1990-9-17
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pubmed:abstractText |
The myelopoietic stimulation which occurs in mice bearing metastatic Lewis lung carcinoma (LLC-C3) tumors is accompanied by immune suppression and the appearance of myelopoiesis-associated immune suppressor cells in the bone marrow and spleen. Low doses of recombinant murine interferon-gamma (IFN-gamma) plus recombinant human tumor necrosis factor-alpha (TNF-alpha) were used to limit myelopoiesis and, in turn, reduce the presence of myelopoiesis-associated immune suppressor cells in LLC-C3 tumor bearers. Neither IFN-gamma nor TNF-alpha alone had any effect in vitro on the growth of myeloid progenitor cells into colonies or on the suppressive activity of bone-marrow cells from LLC-C3-bearing mice. However, the combination of low doses of IFN-gamma and TNF-alpha synergistically inhibited both the growth of myeloid progenitor cells into colonies and the suppressive activity of bone-marrow cells from tumor-bearers. Similar results were obtained in vivo. When used alone, neither IFN-gamma nor TNF-alpha had any effect on myelopoiesis or on suppressor-cell activity. When combined, IFN-gamma plus TNF-alpha synergistically suppressed myelopoiesis and the presence of immune suppressive cells both in the bone marrow and in the spleen of tumor bearers. T-lymphocyte blastogenic and NK cytotoxic activities of the tumor-bearers were restored only after treatment with both IFN-gamma and TNF-alpha.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0020-7136
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
46
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
245-50
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2143498-Animals,
pubmed-meshheading:2143498-Bone Marrow,
pubmed-meshheading:2143498-Colony-Forming Units Assay,
pubmed-meshheading:2143498-Depression, Chemical,
pubmed-meshheading:2143498-Dose-Response Relationship, Drug,
pubmed-meshheading:2143498-Drug Synergism,
pubmed-meshheading:2143498-Hematopoiesis,
pubmed-meshheading:2143498-Immune Tolerance,
pubmed-meshheading:2143498-Interferon-gamma,
pubmed-meshheading:2143498-Lung Neoplasms,
pubmed-meshheading:2143498-Mice,
pubmed-meshheading:2143498-Mice, Inbred C57BL,
pubmed-meshheading:2143498-Recombinant Proteins,
pubmed-meshheading:2143498-T-Lymphocytes, Regulatory,
pubmed-meshheading:2143498-Tumor Necrosis Factor-alpha
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pubmed:year |
1990
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pubmed:articleTitle |
Myelopoiesis-associated suppressor-cell activity in mice with Lewis lung carcinoma tumors: interferon-gamma plus tumor necrosis factor-alpha synergistically reduce suppressor cell activity.
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pubmed:affiliation |
Department of Research Services, Hines V.A. Hospital, IL 60141.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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