Source:http://linkedlifedata.com/resource/pubmed/id/21396350
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2011-4-12
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pubmed:abstractText |
IL-17, which exerts strong pro-inflammatory effects, has emerged as an important mediator in inflammation-associated cancer. However, the characteristics of IL-17-producing cells, the relevance of IL-17 to clinical parameters and its function in the development and progression of colorectal carcinoma still remain to be explored. In the present study, we first found the levels of IL-17 producing cells were significantly increased in the tumor regions of samples from colorectal carcinoma patients compared with non-tumor regions. Confocal microscopic analysis showed co-staining of IL-17 with CD4 and CD68, indicating IL-17 in colorectal carcinoma was expressed by macrophage and Th17. High expression of IL-17 was associated with high microvessel density. Univariate and multivariate analysis revealed that IL-17 was an independent prognostic factor for overall survival. To explore the underlying mechanisms of IL-17 in angiogenesis, we used PCR-array to find pro-angiogenic factor in cancer cells specifically induced by IL-17, then validated VEGF as one of factors in IL-17-mediated angiogenesis with the use of quantitative RT-PCR, ELISA and VEGF immunohistochemistry. Our results propose IL-17 as a novel indicator of prognosis in the patients with colorectal carcinoma and could serve as a novel therapeutic target for colorectal carcinoma, furthermore our results indicate that IL-17 producing cells may facilitate development of colorectal carcinoma by fostering angiogenesis via promote VEGF production from cancer cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD5,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD68 antigen, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1090-2104
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pubmed:author | |
pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
407
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
348-54
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pubmed:meshHeading |
pubmed-meshheading:21396350-Adult,
pubmed-meshheading:21396350-Antigens, CD,
pubmed-meshheading:21396350-Antigens, CD5,
pubmed-meshheading:21396350-Antigens, Differentiation, Myelomonocytic,
pubmed-meshheading:21396350-Carcinoma,
pubmed-meshheading:21396350-Colorectal Neoplasms,
pubmed-meshheading:21396350-Female,
pubmed-meshheading:21396350-Humans,
pubmed-meshheading:21396350-Interleukin-17,
pubmed-meshheading:21396350-Male,
pubmed-meshheading:21396350-Middle Aged,
pubmed-meshheading:21396350-Neovascularization, Pathologic,
pubmed-meshheading:21396350-Prognosis,
pubmed-meshheading:21396350-Vascular Endothelial Growth Factor A,
pubmed-meshheading:21396350-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma.
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pubmed:affiliation |
Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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