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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-3-30
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pubmed:abstractText |
Cyclin-dependent kinase 5 (CDK5) regulatory subunit-associated protein 1-like 1 has recently been linked to type 2 diabetes by genome-wide association studies. While CDK5 and its regulatory protein p35 are both expressed and display enzymatic activity in pancreatic ?-cells, their precise role in the ?-cell remains unknown. Because type 2 diabetes is characterized by a deficit in ?-cell mass and increased ?-cell apoptosis, we investigated the role of CDK5 in ?-cell survival.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1939-327X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1186-97
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pubmed:meshHeading |
pubmed-meshheading:21378178-Animals,
pubmed-meshheading:21378178-Apoptosis,
pubmed-meshheading:21378178-Blotting, Western,
pubmed-meshheading:21378178-Cell Line,
pubmed-meshheading:21378178-Cell Survival,
pubmed-meshheading:21378178-Cyclin-Dependent Kinase 5,
pubmed-meshheading:21378178-Diabetes Mellitus, Type 2,
pubmed-meshheading:21378178-Focal Adhesion Protein-Tyrosine Kinases,
pubmed-meshheading:21378178-Humans,
pubmed-meshheading:21378178-Insulin-Secreting Cells,
pubmed-meshheading:21378178-Islet Amyloid Polypeptide,
pubmed-meshheading:21378178-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:21378178-RNA, Small Interfering,
pubmed-meshheading:21378178-Rats,
pubmed-meshheading:21378178-Rats, Transgenic,
pubmed-meshheading:21378178-Signal Transduction
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pubmed:year |
2011
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pubmed:articleTitle |
Cyclin-dependent kinase 5 promotes pancreatic ?-cell survival via Fak-Akt signaling pathways.
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pubmed:affiliation |
Larry Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA. mdaval@mednet.ucla.edu
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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