Linked Life Data

21377874

Source:http://linkedlifedata.com/resource/pubmed/id/21377874

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-3-14
pubmed:abstractText
In this manuscript, we synthesized a series of phenylpropanoid amide of serotonin 1-9, analyzed their structural importance for two biologic activities (antioxidant activity and tyrosinase inhibitory activity). While the serotonin moiety and the amide linkage of serotonin derivatives affect antioxidant activity strongly, the serotonin moiety, the amide linkage and the cinnamic acid moiety affect tyrosinase inhibitory activity. Among tested compounds, compound 4 which contains cathechol moiety exhibited the most antioxidant activity (EC(50) = 19.4 ± 2.0 ?M), and compound 6 exhibited significant tyrosinase inhibitory activity (IC(50) = 5.4 ± 3.6 ?M). Our data suggests that a useful clue for the design and development of new tyrosinase inhibitors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1464-3405
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1983-6
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Synthesis and structure-activity relationships of phenylpropanoid amides of serotonin on tyrosinase inhibition.
pubmed:affiliation
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, 3-4-1 Kowakae, Higashiosaka-shi, Osaka 577-8502, Japan.
pubmed:publicationType
Journal Article