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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2011-6-6
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pubmed:abstractText |
Regulatory T (Treg) cells (CD4+ CD25high FoxP3+) regulate mucosal tolerance; their adoptive transfer prevents or reduces symptoms of colitis in mouse models of inflammatory bowel disease. Colonic CD90+ mesenchymal myofibroblasts and fibroblasts (CMFs) are abundant, nonprofessional antigen-presenting cells in the normal human colonic mucosa that suppress proliferation of activated CD4+ effector T cells. We studied CMF suppressive capacity and evaluated the ability of CMF to induce Treg cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/FOXP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/IL10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IL2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IL2RA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2 Receptor alpha Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/PTPRC protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2019-30
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:21376048-Antigens, CD45,
pubmed-meshheading:21376048-Cell Proliferation,
pubmed-meshheading:21376048-Cells, Cultured,
pubmed-meshheading:21376048-Coculture Techniques,
pubmed-meshheading:21376048-Colon,
pubmed-meshheading:21376048-Colonic Neoplasms,
pubmed-meshheading:21376048-Dinoprostone,
pubmed-meshheading:21376048-Forkhead Transcription Factors,
pubmed-meshheading:21376048-Histocompatibility Antigens Class II,
pubmed-meshheading:21376048-Humans,
pubmed-meshheading:21376048-Immune Tolerance,
pubmed-meshheading:21376048-Immunity, Mucosal,
pubmed-meshheading:21376048-Inflammatory Bowel Diseases,
pubmed-meshheading:21376048-Interferon-gamma,
pubmed-meshheading:21376048-Interleukin-10,
pubmed-meshheading:21376048-Interleukin-2,
pubmed-meshheading:21376048-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:21376048-Lymphocyte Activation,
pubmed-meshheading:21376048-Myofibroblasts,
pubmed-meshheading:21376048-Paracrine Communication,
pubmed-meshheading:21376048-Phenotype,
pubmed-meshheading:21376048-Signal Transduction,
pubmed-meshheading:21376048-T-Lymphocytes, Regulatory,
pubmed-meshheading:21376048-Time Factors,
pubmed-meshheading:21376048-Transforming Growth Factor beta
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pubmed:year |
2011
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pubmed:articleTitle |
Human colonic myofibroblasts promote expansion of CD4+ CD25high Foxp3+ regulatory T cells.
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pubmed:affiliation |
Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555-0655, USA.
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pubmed:publicationType |
Journal Article
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