| pubmed-article:2137008 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2137008 | lifeskim:mentions | umls-concept:C0015859 | lld:lifeskim |
| pubmed-article:2137008 | lifeskim:mentions | umls-concept:C0042963 | lld:lifeskim |
| pubmed-article:2137008 | lifeskim:mentions | umls-concept:C0003297 | lld:lifeskim |
| pubmed-article:2137008 | lifeskim:mentions | umls-concept:C0010583 | lld:lifeskim |
| pubmed-article:2137008 | lifeskim:mentions | umls-concept:C0011777 | lld:lifeskim |
| pubmed-article:2137008 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:2137008 | lifeskim:mentions | umls-concept:C2917412 | lld:lifeskim |
| pubmed-article:2137008 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2137008 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2137008 | pubmed:dateCreated | 1990-3-7 | lld:pubmed |
| pubmed-article:2137008 | pubmed:abstractText | A new group of selective 5HT3 antagonists are proving to be effective anti-emetics for cytotoxic and radiation induced vomiting in both animal models and man. Current anti-emetic regimens often benefit from combination therapy, in particular the efficacy of metoclopramide (which can be a weak 5HT3 antagonist), can be improved by combination with dexamethasone, another anti-emetic. Hence it was of interest to evaluate whether a 5HT3 receptor antagonist GR38032F could be improved by combination with dexamethasone. Vomiting induced by cyclophosphamide in the ferret was observed after pre-treatment with dexamethasone alone or in combination with GR38032F. Animals were also observed for signs of 'nausea'. Dexamethasone alone proved a weak anti-emetic in this system but did have significant effects on 'nausea'. GR38032F has previously been shown to be capable of totally controlling emesis due to cyclophosphamide in the ferret. Here a dose of GR38032F that is not 100% effective was employed; this was shown to have effects on 'nausea' but most interestingly its anti-emetic action was increased by combination with dexamethasone. This may be important for the minority of patients whose vomiting is not completely controlled by GR38032F alone. | lld:pubmed |
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| pubmed-article:2137008 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2137008 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2137008 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2137008 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2137008 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2137008 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:2137008 | pubmed:author | pubmed-author:HawthornJJ | lld:pubmed |
| pubmed-article:2137008 | pubmed:author | pubmed-author:CunninghamDD | lld:pubmed |
| pubmed-article:2137008 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2137008 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:2137008 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2137008 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2137008 | pubmed:pagination | 56-60 | lld:pubmed |
| pubmed-article:2137008 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2137008 | pubmed:meshHeading | pubmed-meshheading:2137008-... | lld:pubmed |
| pubmed-article:2137008 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2137008 | pubmed:articleTitle | Dexamethasone can potentiate the anti-emetic action of a 5HT3 receptor antagonist on cyclophosphamide induced vomiting in the ferret. | lld:pubmed |
| pubmed-article:2137008 | pubmed:affiliation | Department of Physiology, St Georges Hospital Medical School, London, UK. | lld:pubmed |
| pubmed-article:2137008 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2137008 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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