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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1990-3-7
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pubmed:abstractText |
A new group of selective 5HT3 antagonists are proving to be effective anti-emetics for cytotoxic and radiation induced vomiting in both animal models and man. Current anti-emetic regimens often benefit from combination therapy, in particular the efficacy of metoclopramide (which can be a weak 5HT3 antagonist), can be improved by combination with dexamethasone, another anti-emetic. Hence it was of interest to evaluate whether a 5HT3 receptor antagonist GR38032F could be improved by combination with dexamethasone. Vomiting induced by cyclophosphamide in the ferret was observed after pre-treatment with dexamethasone alone or in combination with GR38032F. Animals were also observed for signs of 'nausea'. Dexamethasone alone proved a weak anti-emetic in this system but did have significant effects on 'nausea'. GR38032F has previously been shown to be capable of totally controlling emesis due to cyclophosphamide in the ferret. Here a dose of GR38032F that is not 100% effective was employed; this was shown to have effects on 'nausea' but most interestingly its anti-emetic action was increased by combination with dexamethasone. This may be important for the minority of patients whose vomiting is not completely controlled by GR38032F alone.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-2566845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-2841996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-2851311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-2883502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-2885454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-2964267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-3297375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-3297376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-3347698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-3375446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-3670559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-3742146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-3774121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-3797636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-3839291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-3855968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-544584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-6122510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-6342770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-6434122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-6527747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-6681766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-7024807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-7189499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137008-7198011
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
56-60
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2137008-Animals,
pubmed-meshheading:2137008-Cyclophosphamide,
pubmed-meshheading:2137008-Dexamethasone,
pubmed-meshheading:2137008-Drug Synergism,
pubmed-meshheading:2137008-Drug Therapy, Combination,
pubmed-meshheading:2137008-Female,
pubmed-meshheading:2137008-Ferrets,
pubmed-meshheading:2137008-Imidazoles,
pubmed-meshheading:2137008-Male,
pubmed-meshheading:2137008-Ondansetron,
pubmed-meshheading:2137008-Serotonin Antagonists,
pubmed-meshheading:2137008-Vomiting
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pubmed:year |
1990
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pubmed:articleTitle |
Dexamethasone can potentiate the anti-emetic action of a 5HT3 receptor antagonist on cyclophosphamide induced vomiting in the ferret.
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pubmed:affiliation |
Department of Physiology, St Georges Hospital Medical School, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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