| pubmed-article:21330350 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21330350 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:21330350 | lifeskim:mentions | umls-concept:C0384648 | lld:lifeskim |
| pubmed-article:21330350 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:21330350 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:21330350 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:21330350 | lifeskim:mentions | umls-concept:C0013126 | lld:lifeskim |
| pubmed-article:21330350 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:21330350 | lifeskim:mentions | umls-concept:C1149201 | lld:lifeskim |
| pubmed-article:21330350 | lifeskim:mentions | umls-concept:C1537403 | lld:lifeskim |
| pubmed-article:21330350 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:21330350 | lifeskim:mentions | umls-concept:C1511636 | lld:lifeskim |
| pubmed-article:21330350 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:21330350 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:21330350 | lifeskim:mentions | umls-concept:C1363844 | lld:lifeskim |
| pubmed-article:21330350 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:21330350 | pubmed:dateCreated | 2011-5-2 | lld:pubmed |
| pubmed-article:21330350 | pubmed:abstractText | The immune system in early life is regarded as immature. However, the IL-12 family member IL-23 is highly produced upon TLR stimulation by neonatal DCs. Human adult V?9V?2 T cells can be stimulated specifically via their TCR by phosphoantigens (as the pathogen-derived HMB-PP) or agents and infections that lead to their endogenous accumulation (as the aminobisphosphonate zoledronate). As increasing evidence indicates that ?? T cells are especially important in early life, we investigated the effect of IL-23 on neonatal V?9V?2 T cells stimulated via their TCR. Zoledronate induced clear proliferation and IFN-? production in neonatal V?9V?2 T cells. In contrast, HMB-PP did not elicit a distinct response unless at high concentrations. Addition of IL-23 to zoledronate enhanced the expression of IFN-? and generated a distinct, IFN-?-negative, neonatal V?9V?2 T cell population producing IL-17. Furthermore, IL-23 significantly enhanced the expression of a range of cytotoxic mediators (perforin, granzymes, granulysin). Although the costimulatory effect of IL-23 on IFN-? and cytotoxic mediators was also observed within adult V?9V?2 T cells, the induction of an IL-17+IFN-?- subset was unique to neonatal V?9V?2 T cells. In conclusion, neonatal DC-derived IL-23 combined with specific TCR signaling drives the generation of neonatal V?9V?2 T cells equipped with a range of cytotoxic mediators and distinct subpopulations producing IFN-? and IL-17. | lld:pubmed |
| pubmed-article:21330350 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21330350 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330350 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21330350 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330350 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330350 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330350 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330350 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330350 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330350 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330350 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330350 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330350 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330350 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330350 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330350 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330350 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330350 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21330350 | pubmed:month | May | lld:pubmed |
| pubmed-article:21330350 | pubmed:issn | 1938-3673 | lld:pubmed |
| pubmed-article:21330350 | pubmed:author | pubmed-author:GoldmanMichel... | lld:pubmed |
| pubmed-article:21330350 | pubmed:author | pubmed-author:WillemsFabien... | lld:pubmed |
| pubmed-article:21330350 | pubmed:author | pubmed-author:BrouwerMargre... | lld:pubmed |
| pubmed-article:21330350 | pubmed:author | pubmed-author:VermijlenDavi... | lld:pubmed |
| pubmed-article:21330350 | pubmed:author | pubmed-author:MoensEmmanuel... | lld:pubmed |
| pubmed-article:21330350 | pubmed:author | pubmed-author:DimovaTanyaT | lld:pubmed |
| pubmed-article:21330350 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21330350 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:21330350 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21330350 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21330350 | pubmed:pagination | 743-52 | lld:pubmed |
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| pubmed-article:21330350 | pubmed:meshHeading | pubmed-meshheading:21330350... | lld:pubmed |
| pubmed-article:21330350 | pubmed:meshHeading | pubmed-meshheading:21330350... | lld:pubmed |
| pubmed-article:21330350 | pubmed:meshHeading | pubmed-meshheading:21330350... | lld:pubmed |
| pubmed-article:21330350 | pubmed:meshHeading | pubmed-meshheading:21330350... | lld:pubmed |
| pubmed-article:21330350 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21330350 | pubmed:articleTitle | IL-23R and TCR signaling drives the generation of neonatal Vgamma9Vdelta2 T cells expressing high levels of cytotoxic mediators and producing IFN-gamma and IL-17. | lld:pubmed |
| pubmed-article:21330350 | pubmed:affiliation | Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium. | lld:pubmed |
| pubmed-article:21330350 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21330350 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:21330350 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
