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rdf:type |
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lifeskim:mentions |
umls-concept:C0013126,
umls-concept:C0021289,
umls-concept:C0034790,
umls-concept:C0037083,
umls-concept:C0039194,
umls-concept:C0079411,
umls-concept:C0127400,
umls-concept:C0384648,
umls-concept:C0441889,
umls-concept:C1149201,
umls-concept:C1363844,
umls-concept:C1511636,
umls-concept:C1537403,
umls-concept:C1710082
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pubmed:issue |
5
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pubmed:dateCreated |
2011-5-2
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pubmed:abstractText |
The immune system in early life is regarded as immature. However, the IL-12 family member IL-23 is highly produced upon TLR stimulation by neonatal DCs. Human adult V?9V?2 T cells can be stimulated specifically via their TCR by phosphoantigens (as the pathogen-derived HMB-PP) or agents and infections that lead to their endogenous accumulation (as the aminobisphosphonate zoledronate). As increasing evidence indicates that ?? T cells are especially important in early life, we investigated the effect of IL-23 on neonatal V?9V?2 T cells stimulated via their TCR. Zoledronate induced clear proliferation and IFN-? production in neonatal V?9V?2 T cells. In contrast, HMB-PP did not elicit a distinct response unless at high concentrations. Addition of IL-23 to zoledronate enhanced the expression of IFN-? and generated a distinct, IFN-?-negative, neonatal V?9V?2 T cell population producing IL-17. Furthermore, IL-23 significantly enhanced the expression of a range of cytotoxic mediators (perforin, granzymes, granulysin). Although the costimulatory effect of IL-23 on IFN-? and cytotoxic mediators was also observed within adult V?9V?2 T cells, the induction of an IL-17+IFN-?- subset was unique to neonatal V?9V?2 T cells. In conclusion, neonatal DC-derived IL-23 combined with specific TCR signaling drives the generation of neonatal V?9V?2 T cells equipped with a range of cytotoxic mediators and distinct subpopulations producing IFN-? and IL-17.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Diphosphonates,
http://linkedlifedata.com/resource/pubmed/chemical/GNLY protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Granzymes,
http://linkedlifedata.com/resource/pubmed/chemical/IL23R protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/Perforin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/T-cell receptor Vdelta2, human,
http://linkedlifedata.com/resource/pubmed/chemical/T-cell receptor Vgamma9, human,
http://linkedlifedata.com/resource/pubmed/chemical/zoledronic acid
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1938-3673
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
743-52
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pubmed:meshHeading |
pubmed-meshheading:21330350-Adult,
pubmed-meshheading:21330350-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:21330350-Cell Proliferation,
pubmed-meshheading:21330350-Cells, Cultured,
pubmed-meshheading:21330350-Dendritic Cells,
pubmed-meshheading:21330350-Diphosphonates,
pubmed-meshheading:21330350-Flow Cytometry,
pubmed-meshheading:21330350-Genes, T-Cell Receptor,
pubmed-meshheading:21330350-Granzymes,
pubmed-meshheading:21330350-Humans,
pubmed-meshheading:21330350-Imidazoles,
pubmed-meshheading:21330350-Infant, Newborn,
pubmed-meshheading:21330350-Interferon-gamma,
pubmed-meshheading:21330350-Interleukin-17,
pubmed-meshheading:21330350-Perforin,
pubmed-meshheading:21330350-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:21330350-Receptors, Interleukin,
pubmed-meshheading:21330350-Signal Transduction,
pubmed-meshheading:21330350-T-Lymphocyte Subsets
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pubmed:year |
2011
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pubmed:articleTitle |
IL-23R and TCR signaling drives the generation of neonatal Vgamma9Vdelta2 T cells expressing high levels of cytotoxic mediators and producing IFN-gamma and IL-17.
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pubmed:affiliation |
Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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