| pubmed-article:21316198 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21316198 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:21316198 | lifeskim:mentions | umls-concept:C0023977 | lld:lifeskim |
| pubmed-article:21316198 | lifeskim:mentions | umls-concept:C0001699 | lld:lifeskim |
| pubmed-article:21316198 | lifeskim:mentions | umls-concept:C0002645 | lld:lifeskim |
| pubmed-article:21316198 | lifeskim:mentions | umls-concept:C0055860 | lld:lifeskim |
| pubmed-article:21316198 | lifeskim:mentions | umls-concept:C1522618 | lld:lifeskim |
| pubmed-article:21316198 | lifeskim:mentions | umls-concept:C0370215 | lld:lifeskim |
| pubmed-article:21316198 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:21316198 | lifeskim:mentions | umls-concept:C0206173 | lld:lifeskim |
| pubmed-article:21316198 | lifeskim:mentions | umls-concept:C1552228 | lld:lifeskim |
| pubmed-article:21316198 | lifeskim:mentions | umls-concept:C0205099 | lld:lifeskim |
| pubmed-article:21316198 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:21316198 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:21316198 | pubmed:dateCreated | 2011-4-11 | lld:pubmed |
| pubmed-article:21316198 | pubmed:abstractText | The aim of this work was to investigate the molecular epidemiology and mechanisms responsible for reduced susceptibility to amoxicillin/clavulanic acid (AMC) amongst cefazolin-susceptible Klebsiella pneumoniae isolates from patients admitted to a chronic care institution. In total, 51 (29.8%) of 171 K. pneumoniae isolates recovered between 2006 and 2008 were non-susceptible to AMC, of which 45 were susceptible to cefazolin. Nucleotide sequencing analysis revealed that 19 produced IRT-11 and the remaining 26 were OXA-1-producers. All of the OXA-1-producing isolates harboured the aac(6')-Ib-cr-bla(OXA-1) cassette array, which in 23 isolates was located together with catB3 and arr3 within a class 1 integron and associated with qnrS2 (in 3 cases the integron lacked the qacE?1 and sul1 or sul3 genes). Genotyping analysis performed by enterobacterial repetitive intergenic consensus polymerase chain reaction (ERIC-PCR) identified three different patterns amongst IRT-11-producing isolates (E1 to E3), with E1 being the most prevalent (63.2%), whilst the OXA-1-producing isolates were assigned to patterns E3 and E3a (isolates carrying typical class 1 integrons), E4 (isolates carrying defective integrons) and E5 (isolates without integrons). Genes encoding IRT-11 and OXA-1 were transferred by conjugation, and aac(6')-Ib-cr and qnrS2 were systematically co-transferred with bla(OXA-1). These results demonstrate that the high prevalence of decreased susceptibility to AMC amongst K. pneumoniae isolates from a chronic care hospital was mainly due to the simultaneous spread of two different clones, one of which comprised isolates producing IRT-11 and the other one comprised isolates that had acquired either the bla(OXA-1) gene located in a class 1 integron and linked to qnrS2 or the bla(IRT-11) gene. | lld:pubmed |
| pubmed-article:21316198 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21316198 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21316198 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21316198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21316198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21316198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21316198 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21316198 | pubmed:month | May | lld:pubmed |
| pubmed-article:21316198 | pubmed:issn | 1872-7913 | lld:pubmed |
| pubmed-article:21316198 | pubmed:author | pubmed-author:RuizJoaquimJ | lld:pubmed |
| pubmed-article:21316198 | pubmed:author | pubmed-author:Pérez-MorenoM... | lld:pubmed |
| pubmed-article:21316198 | pubmed:author | pubmed-author:Jardí-BaigesA... | lld:pubmed |
| pubmed-article:21316198 | pubmed:author | pubmed-author:Centelles-Ser... | lld:pubmed |
| pubmed-article:21316198 | pubmed:author | pubmed-author:Cortell-Ortol... | lld:pubmed |
| pubmed-article:21316198 | pubmed:author | pubmed-author:Llovet-Lombar... | lld:pubmed |
| pubmed-article:21316198 | pubmed:author | pubmed-author:Fort-GallifaI... | lld:pubmed |
| pubmed-article:21316198 | pubmed:author | pubmed-author:Picó-PlanaEst... | lld:pubmed |
| pubmed-article:21316198 | pubmed:copyrightInfo | Copyright © 2011 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved. | lld:pubmed |
| pubmed-article:21316198 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21316198 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:21316198 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21316198 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21316198 | pubmed:pagination | 462-6 | lld:pubmed |
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| pubmed-article:21316198 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21316198 | pubmed:articleTitle | Molecular epidemiology and resistance mechanisms involved in reduced susceptibility to amoxicillin/clavulanic acid in Klebsiella pneumoniae isolates from a chronic care centre. | lld:pubmed |
| pubmed-article:21316198 | pubmed:affiliation | Servei Anàlisis Clíniques, Hospital de Tortosa Verge de la Cinta, C/Esplanetes s/n 43500 Tortosa, Spain. marolgap@terra.es | lld:pubmed |
| pubmed-article:21316198 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21316198 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
