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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1991-10-18
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pubmed:abstractText |
Serum samples from cancer patients receiving intravenous infusions of recombinant tumor necrosis factor (rTNF) and recombinant interferon-gamma (rIFN-gamma) were analyzed for TNF and the TNF-binding protein (TNF-BP). TNF-BP is a soluble fragment of the transmembrane TNF receptor with antagonistic effects to TNF and is released by proteolytic cleavage of the receptor. During a 60-min infusion of rTNF, peak serum levels of rTNF were observed after 30 to 60 min and a transient increase of circulating TNF-BP was observed with peak levels between 30 and 120 min. Injection of IFN-gamma alone did not affect the levels of TNF and TNF-BP. Thus administration of rTNF leads to release into the circulation of TNF-BP, which may modulate both systemic and local effects of TNF and influence its therapeutic efficacy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1043-4666
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
402-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2129506-Carrier Proteins,
pubmed-meshheading:2129506-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:2129506-Humans,
pubmed-meshheading:2129506-Infusions, Intravenous,
pubmed-meshheading:2129506-Interferon-gamma,
pubmed-meshheading:2129506-Kinetics,
pubmed-meshheading:2129506-Neoplasms,
pubmed-meshheading:2129506-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:2129506-Receptors, Tumor Necrosis Factor, Type I,
pubmed-meshheading:2129506-Recombinant Proteins,
pubmed-meshheading:2129506-Time Factors,
pubmed-meshheading:2129506-Tumor Necrosis Factor Decoy Receptors,
pubmed-meshheading:2129506-Tumor Necrosis Factor-alpha
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pubmed:year |
1990
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pubmed:articleTitle |
Infusion of tumor necrosis factor (TNF) causes an increase in circulating TNF-binding protein in humans.
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pubmed:affiliation |
Division of Hematology, Department of Medicine, Lund, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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