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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-2-1
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pubmed:abstractText |
Regardless of their primary causes, progressive renal fibrosis and tubular atrophy are the main predictors of progression to end-stage renal disease. Basigin/CD147 is a multifunctional molecule-it induces matrix metalloproteinases and hyaluronan, for example-and has been implicated in organ fibrosis. However, the relationship between basigin and organ fibrosis has been poorly studied. We investigated basigin's role in renal fibrosis using a unilateral ureteral obstruction model. Basigin-deficient mice (Bsg(-/-)) demonstrated significantly less fibrosis after surgery than Bsg(+/+) mice. Fewer macrophages had infiltrated in Bsg(-/-) kidneys. Consistent with these in vivo data, primary cultured tubular epithelial cells from Bsg(-/-) mice produced less matrix metalloproteinase and exhibited less motility on stimulation with transforming growth factor ?. Furthermore, Bsg(-/-) embryonic fibro blasts produced less hyaluronan and ?-smooth muscle actin after transforming growth factor ? stimulation. Together, these results demonstrate for the first time that basigin is a key regulator of renal fibrosis. Basigin could be a candidate target molecule for the prevention of organ fibrosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1525-2191
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pubmed:author |
pubmed-author:IshimotoTakujiT,
pubmed-author:KadomatsuKenjiK,
pubmed-author:KatoNoritoshiN,
pubmed-author:KojimaHiroshiH,
pubmed-author:KosugiTomokiT,
pubmed-author:MaruyamaShoichiS,
pubmed-author:MatsuoSeiichiS,
pubmed-author:SakamotoKazumaK,
pubmed-author:SatoWaichiW,
pubmed-author:SatoYukaY,
pubmed-author:YuzawaYukioY
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pubmed:copyrightInfo |
Copyright © 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
178
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
572-9
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pubmed:meshHeading |
pubmed-meshheading:21281789-Animals,
pubmed-meshheading:21281789-Antigens, CD147,
pubmed-meshheading:21281789-Cell Movement,
pubmed-meshheading:21281789-Disease Models, Animal,
pubmed-meshheading:21281789-Epithelial Cells,
pubmed-meshheading:21281789-Fibrosis,
pubmed-meshheading:21281789-Hyaluronic Acid,
pubmed-meshheading:21281789-Kidney,
pubmed-meshheading:21281789-Kidney Diseases,
pubmed-meshheading:21281789-Kidney Tubules,
pubmed-meshheading:21281789-Macrophages,
pubmed-meshheading:21281789-Matrix Metalloproteinase 2,
pubmed-meshheading:21281789-Matrix Metalloproteinase 9,
pubmed-meshheading:21281789-Mice,
pubmed-meshheading:21281789-Models, Biological,
pubmed-meshheading:21281789-Transforming Growth Factor beta,
pubmed-meshheading:21281789-Up-Regulation,
pubmed-meshheading:21281789-Ureteral Obstruction
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pubmed:year |
2011
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pubmed:articleTitle |
Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction.
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pubmed:affiliation |
Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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