Linked Life Data

21276136

Source:http://linkedlifedata.com/resource/pubmed/id/21276136

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-4-15
pubmed:abstractText
Laminins present in the basement membranes (BM) of blood vessels are involved in angiogenesis and other vascular functions that are critical for tumor growth and metastasis. Two major vascular laminins, the ?4 (laminin-411/421) and ?5 (laminin-511/521) types, have been well characterized. We recently found a third type of vascular laminin, laminin-3B11, consisting of the ?3B, ?1 and ?1 chains, and revealed its biological activity. Laminin-3B11 potently stimulates vascular endothelial cells to extend lamellipodial protrusions. To understand the roles of laminin-3B11 in blood vessel functions and tumor growth, we examined localization of the laminin ?3B chain in normal mammary glands and breast cancers, in comparison with the ?4 and ?5 laminins. In the immunohistochemical analysis, the ?3B laminin was co-localized with the ?4 and ?5 laminins in the BM of venules and capillaries of normal breast tissues, but ?3B was scarcely detected in vessels near invasive breast carcinoma cells. In contrast, the ?4 laminin was overexpressed in capillaries of invasive carcinomas, where a large number of macrophages were found. The ?5 laminin appeared to be weakly downregulated in cancer tissues, especially in capillary vessels. Furthermore, our in vitro analysis indicated that TNF-? significantly suppressed the laminin ?3B expression in vascular endothelial cells, while it, as well as IL-1? and TGF-?, upregulated the ?4 expression. These results suggest that Lm3B11/3B21 may be required for normal mature vessels and interfere with tumor angiogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1349-7006
pubmed:author
pubmed:copyrightInfo
© 2011 Japanese Cancer Association.
pubmed:issnType
Electronic
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1095-100
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Downregulation of a newly identified laminin, laminin-3B11, in vascular basement membranes of invasive human breast cancers.
pubmed:affiliation
Graduate School of Integrated Sciences, Yokohama City University, Yokohama, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't