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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-3-14
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pubmed:abstractText |
Human hypothalamic hamartomas (HHs) are associated with gelastic seizures, intrinsically epileptogenic, and notoriously refractory to medical therapy. We previously reported that the L-type calcium channel antagonist nifedipine blocks spontaneous firing and ?-aminobutyric acid (GABA)(A)-induced depolarization of single cells in HH tissue slices. In this study, we examined whether blocking L-type calcium channels attenuates emergent activity of HH neuronal networks.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1528-1167
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pubmed:author |
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pubmed:copyrightInfo |
Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.
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pubmed:issnType |
Electronic
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
531-40
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pubmed:meshHeading |
pubmed-meshheading:21269296-Adolescent,
pubmed-meshheading:21269296-Adult,
pubmed-meshheading:21269296-Anticonvulsants,
pubmed-meshheading:21269296-Calcium Channel Blockers,
pubmed-meshheading:21269296-Calcium Channels, L-Type,
pubmed-meshheading:21269296-Child,
pubmed-meshheading:21269296-Child, Preschool,
pubmed-meshheading:21269296-Electroencephalography,
pubmed-meshheading:21269296-Epilepsies, Partial,
pubmed-meshheading:21269296-Evoked Potentials,
pubmed-meshheading:21269296-Female,
pubmed-meshheading:21269296-Hamartoma,
pubmed-meshheading:21269296-Humans,
pubmed-meshheading:21269296-Hypothalamic Diseases,
pubmed-meshheading:21269296-Hypothalamus,
pubmed-meshheading:21269296-Infant,
pubmed-meshheading:21269296-Male,
pubmed-meshheading:21269296-Nerve Net,
pubmed-meshheading:21269296-Neurons,
pubmed-meshheading:21269296-Nifedipine,
pubmed-meshheading:21269296-Receptors, GABA-A,
pubmed-meshheading:21269296-Signal Processing, Computer-Assisted,
pubmed-meshheading:21269296-Tissue Culture Techniques,
pubmed-meshheading:21269296-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
L-Type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue.
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pubmed:affiliation |
Divisions of Neurology and Pediatric Neurology, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, Arizona, USA. TimothySimeone@Creighton.edu
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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