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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-26
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pubmed:abstractText |
Asthma is a complex disease linked to various pathophysiological events including the activity of proteinases. The multifunctional A disintegrin and metalloproteinases (ADAMs) displaying the ability to cleave membrane-bound mediators or cytokines appear to be key mediators in various inflammatory processes. In the present study, we investigated ADAM-8 expression and production in a mouse model of allergen-induced airway inflammation. In allergen-exposed animals, increased expression of ADAM-8 was found in the lung parenchyma and in DC purified from the lungs. The potential role of ADAM-8 in the development of allergen-induced airway inflammation was further investigated by the use of an anti-ADAM-8 antibody and ADAM-8 knockout animals. We observed a decrease in allergen-induced acute inflammation both in BALF and the peribronchial area in anti-ADAM-8 antibody-treated mice and in ADAM-8-deficient mice (ADAM-8(-/-) ) after allergen exposure. ADAM-8 depletion led to a significant decrease of the CD11c(+) lung DC. We also report lower levels of CCL11 and CCL22 production in antibody-treated mice and ADAM-8- deficient mice that might be explained by decreased eosinophilic inflammation and lower numbers of DC, respectively. In conclusion, ADAM-8 appears to favour allergen-induced acute airway inflammation by promoting DC recruitment and CCL11 and CCL22 production.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADAM Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Adam8 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Ccl11 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ccl22 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL11,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL22,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1521-4141
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pubmed:author |
pubmed-author:BedoretDenisD,
pubmed-author:BekaertSandrineS,
pubmed-author:BureauFabriceF,
pubmed-author:CataldoDidier DDD,
pubmed-author:CrahayCélineC,
pubmed-author:DesmetChristopheC,
pubmed-author:FoidartJean-MichelJM,
pubmed-author:GuédersMaud MMM,
pubmed-author:HachaJonathanJ,
pubmed-author:NoelAgnèsA,
pubmed-author:PaulissenGenevièveG,
pubmed-author:Quesada-CalvoFlorenceF,
pubmed-author:RocksNatachaN
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pubmed:copyrightInfo |
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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pubmed:issnType |
Electronic
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
380-91
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pubmed:meshHeading |
pubmed-meshheading:21268008-ADAM Proteins,
pubmed-meshheading:21268008-Animals,
pubmed-meshheading:21268008-Antibodies,
pubmed-meshheading:21268008-Antigens, CD,
pubmed-meshheading:21268008-Asthma,
pubmed-meshheading:21268008-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:21268008-Cell Count,
pubmed-meshheading:21268008-Cell Movement,
pubmed-meshheading:21268008-Chemokine CCL11,
pubmed-meshheading:21268008-Chemokine CCL22,
pubmed-meshheading:21268008-Cytokines,
pubmed-meshheading:21268008-Eosinophils,
pubmed-meshheading:21268008-Gene Expression,
pubmed-meshheading:21268008-Inflammation,
pubmed-meshheading:21268008-Lung,
pubmed-meshheading:21268008-Macrophages, Alveolar,
pubmed-meshheading:21268008-Male,
pubmed-meshheading:21268008-Membrane Proteins,
pubmed-meshheading:21268008-Mice,
pubmed-meshheading:21268008-Mice, Inbred BALB C,
pubmed-meshheading:21268008-Mice, Inbred C57BL,
pubmed-meshheading:21268008-Mice, Knockout,
pubmed-meshheading:21268008-Ovalbumin,
pubmed-meshheading:21268008-Vaccination
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pubmed:year |
2011
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pubmed:articleTitle |
ADAM-8, a metalloproteinase, drives acute allergen-induced airway inflammation.
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pubmed:affiliation |
Laboratory of Tumor and Development Biology, GIGA-Research (GIGA-I3 and GIGA-cancer), University of Liege and CHU of Liege, Sart-Tilman, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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