Linked Life Data

21264890

Source:http://linkedlifedata.com/resource/pubmed/id/21264890

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-1-25
pubmed:abstractText
Lipopolysaccharide (LPS)-induced inflammatory factors production by the cerebral cortical glial cells in two sides of the murine brain are different. To determine if microglial cells, a subset of glial cells, are involved in asymmetric production, interleukin-6 (IL-6), interleukin-1? (IL-1?) and nitric oxide (NO) responses to LPS by microglial cells in the right and left cerebral cortices were examined. Primary microglial cells were isolated from BALB/C neonatal mice, treated with LPS (10?µg?ml(-1) ) for 24?h and examined for IL-6, IL-1? and NO production. At untreated state, the levels of IL-6, IL-1? and NO showed no statistical difference between left and right. However, after LPS treatment, the levels of IL-6, IL-1? and NO for the right microglial cells was statistically significant higher than the left (P?<?0·05). Our results denote that enhanced production of IL-6, IL-1? and NO after LPS treatment in microglia is directly proportional to their basal-state levels, and right cortical microglia produce higher levels of IL-6, IL-1? and NO than left cortical microglia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1099-0844
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 John Wiley & Sons, Ltd.
pubmed:issnType
Electronic
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
50-4
pubmed:meshHeading
pubmed:articleTitle
Lipopolysaccharide enhances asymmetrical production of cytokines and nitric oxide by left and right cerebral cortical microglial cells in BALB/C mice.
pubmed:affiliation
Department of Microbiology and Immunology, The Key Immunopathology Laboratory of Guangdong Province, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong, P.R. China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't