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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1991-1-25
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pubmed:abstractText |
Previously it was demonstrated that malignant transformation of the Syrian hamster cheek pouch mucosa is associated with the expression of TGF-alpha. Therefore in situ hybridization and immunohistochemistry was used to investigate the cellular sources of TGF-alpha production in this model system. Surprisingly one cell type in the inflammatory infiltrate present in the connective tissue adjacent to the transformed epithelium represented a major source of TGF-alpha mRNA. Detailed analysis of these cells revealed that they were eosinophils. In addition to TGF-alpha mRNA, about 40% of the eosinophils associated with the oral tumors exhibited TGF-alpha product reactive with a monoclonal antibody against the C terminus of the mature TGF-alpha peptide. Normal hamster bone marrow eosinophils also exhibited TGF-alpha mRNA and product by in situ hybridization and immunohistochemistry. These results suggest that the eosinophil represents a biologically significant source of TGF-alpha.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-1696954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-211512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-2333283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-2374592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-2422759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-2442615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-2452686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-2460564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-2464440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-2469965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-2510930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-2524008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-2645058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-2723016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-2915167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-2962900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-3041594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-3044605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-3175624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-3258795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-3279155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-3464598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-3467839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-3475565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-4557243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-6457299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124414-7412807
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
1425-34
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2124414-9,10-Dimethyl-1,2-benzanthracene,
pubmed-meshheading:2124414-Animals,
pubmed-meshheading:2124414-Bone Marrow,
pubmed-meshheading:2124414-Bone Marrow Cells,
pubmed-meshheading:2124414-Cricetinae,
pubmed-meshheading:2124414-Eosinophils,
pubmed-meshheading:2124414-Immunohistochemistry,
pubmed-meshheading:2124414-Mesocricetus,
pubmed-meshheading:2124414-Mouth Neoplasms,
pubmed-meshheading:2124414-RNA, Messenger,
pubmed-meshheading:2124414-Reference Values,
pubmed-meshheading:2124414-Transforming Growth Factor alpha
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pubmed:year |
1990
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pubmed:articleTitle |
Production of transforming growth factor alpha by hamster eosinophils.
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pubmed:affiliation |
Department of Oral Medicine and Oral Pathology, Harvard School of Dental Medicine, Boston, Massachusetts 02115.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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