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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-2-28
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pubmed:abstractText |
Tetraspanin CD151 mainly associates with laminin-binding integrins and forms CD151-integrin complex. We previously reported that CD151 could be a potential target for angiogenesis, but the mechanisms involved are still unclear. This study investigated the role of CD151-integrin complex in angiogenesis and the signaling mechanisms involved. Here we showed that CD151 and CD151-AAA mutant were both well expressed at the protein level. CD151 gene transfer promoted angiogenesis and improved skin temperature of the lateral ischemic hindlimb, whereas CD151-AAA mutant abrogated the increase in capillary density and skin temperature. Further, CD151-AAA mutant failed to activate the FAK, ERK, PI3K/Akt/eNOS, and Rac1/Cdc42 signaling pathways. Moreover, CD151-AAA mutant was unavailable to promote bovine aortic endothelial cells (BAECs) proliferation and migration, in contrast to the effects of CD151. The results suggested that formation of CD151-integrin complex was likely to be a prerequisite for CD151-induced angiogenesis and signaling pathways.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1878-5875
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
642-50
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21237282-Animals,
pubmed-meshheading:21237282-Antigens, CD,
pubmed-meshheading:21237282-Antigens, CD151,
pubmed-meshheading:21237282-Base Sequence,
pubmed-meshheading:21237282-Capillaries,
pubmed-meshheading:21237282-Cattle,
pubmed-meshheading:21237282-Cell Cycle,
pubmed-meshheading:21237282-Cell Movement,
pubmed-meshheading:21237282-Cell Proliferation,
pubmed-meshheading:21237282-Dependovirus,
pubmed-meshheading:21237282-Endothelial Cells,
pubmed-meshheading:21237282-Extracellular Space,
pubmed-meshheading:21237282-Gene Expression Regulation,
pubmed-meshheading:21237282-Humans,
pubmed-meshheading:21237282-Integrin alpha3,
pubmed-meshheading:21237282-Integrin alpha6,
pubmed-meshheading:21237282-Male,
pubmed-meshheading:21237282-Mutation,
pubmed-meshheading:21237282-Neovascularization, Physiologic,
pubmed-meshheading:21237282-Protein Binding,
pubmed-meshheading:21237282-Rats,
pubmed-meshheading:21237282-Rats, Wistar,
pubmed-meshheading:21237282-Signal Transduction,
pubmed-meshheading:21237282-Skin Temperature,
pubmed-meshheading:21237282-Wound Healing
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pubmed:year |
2011
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pubmed:articleTitle |
Role of tetraspanin CD151-?3/?6 integrin complex: Implication in angiogenesis CD151-integrin complex in angiogenesis.
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pubmed:affiliation |
Department of Cardiology of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave., Wuhan 430030, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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