rdf:type |
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0033268,
umls-concept:C0086418,
umls-concept:C0205245,
umls-concept:C0214743,
umls-concept:C0218229,
umls-concept:C0384648,
umls-concept:C0599946,
umls-concept:C1171362,
umls-concept:C1515670,
umls-concept:C1705947,
umls-concept:C1825592,
umls-concept:C2936411
|
pubmed:issue |
4
|
pubmed:dateCreated |
2011-4-4
|
pubmed:abstractText |
IL-13 is a central mediator of airway responsiveness and mucus expression in patients with allergic airway inflammation, and IL-13 is currently a therapeutic target for asthma. However, little is known about how IL-13 regulates human CD4(+) T-cell lineages because IL-13 receptor (IL-13R) ?1, a subunit of IL-13R, has not previously been reported to exist on human T cells.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
1097-6825
|
pubmed:author |
|
pubmed:copyrightInfo |
Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
|
pubmed:issnType |
Electronic
|
pubmed:volume |
127
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1006-13.e1-4
|
pubmed:meshHeading |
pubmed-meshheading:21236478-Cell Separation,
pubmed-meshheading:21236478-Flow Cytometry,
pubmed-meshheading:21236478-Humans,
pubmed-meshheading:21236478-Immunoblotting,
pubmed-meshheading:21236478-Interleukin-13,
pubmed-meshheading:21236478-Interleukin-13 Receptor alpha1 Subunit,
pubmed-meshheading:21236478-Interleukin-17,
pubmed-meshheading:21236478-Lymphocyte Activation,
pubmed-meshheading:21236478-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21236478-Signal Transduction,
pubmed-meshheading:21236478-T-Lymphocyte Subsets,
pubmed-meshheading:21236478-Th17 Cells
|
pubmed:year |
2011
|
pubmed:articleTitle |
Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production.
|
pubmed:affiliation |
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. dawn.newcomb@vanderbilt.edu
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
|