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rdf:type |
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lifeskim:mentions |
umls-concept:C0028158,
umls-concept:C0036679,
umls-concept:C0040300,
umls-concept:C0054874,
umls-concept:C0178499,
umls-concept:C0178539,
umls-concept:C0237868,
umls-concept:C0243077,
umls-concept:C0441655,
umls-concept:C0871633,
umls-concept:C1527178,
umls-concept:C2698650
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|
pubmed:issue |
3
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|
pubmed:dateCreated |
2011-1-24
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|
pubmed:abstractText |
Based on the theoretical understanding of the in vivo lysosomotropism, by adjusting the pk(a) of basic nitrogen containing cathepsin S inhibitors, a set of compounds with pk(a) 6-8 were identified to have excellent cell based Lip10 activity, yet avoiding undesired sequestration in spleen.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Feb
|
|
pubmed:issn |
1464-3405
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|
pubmed:author |
pubmed-author:ArbuckleWullieW,
pubmed-author:BaughMarkM,
pubmed-author:BelshawSimoneS,
pubmed-author:BennettD JonathanDJ,
pubmed-author:BruinJohnJ,
pubmed-author:CaiJiaqiangJ,
pubmed-author:CameronKenneth SKS,
pubmed-author:ClaxtonChrisC,
pubmed-author:DempsterMaureenM,
pubmed-author:EverettKathrynK,
pubmed-author:FraderaXavierX,
pubmed-author:HamiltonWilliamW,
pubmed-author:JonesPhilip SPS,
pubmed-author:KinghornEmmaE,
pubmed-author:LongCliveC,
pubmed-author:MartinIainI,
pubmed-author:RobinsonJohnJ,
pubmed-author:WestwoodPaulP
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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|
pubmed:day |
1
|
|
pubmed:volume |
21
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
932-5
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pubmed:meshHeading |
|
|
pubmed:year |
2011
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|
pubmed:articleTitle |
1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors: separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen pka.
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pubmed:affiliation |
Merck Research laboratories, MSD, Lanarkshire ML1 5SH, United Kingdom.
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pubmed:publicationType |
Journal Article
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