Source:http://linkedlifedata.com/resource/pubmed/id/21224059
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2011-1-12
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| pubmed:abstractText |
In this study, we report the unique role of arachidonate 5-lipoxygenase (Alox5) in the regulation of specific humoral immune responses. We previously reported an L22 monoclonal antibody with which human primary resting B cells in the mantle zones of lymphoid follicles are well-defined. Proteomics analyses enabled identification of an L22 antigen as Alox5, which was highly expressed by naive and memory B cells surrounding germinal centers. Cellular growth of mantle cell lymphoma cells also seemed to depend on Alox5. Alox5(-/-) mice exhibited weak antibody responses specific to foreign antigens at the initial and recall phases. This was probably attributable to the low number of follicular and memory B cells and the functional loss of interleukin-21-mediated responses of follicular B cells. Moreover, Alox5(-/-) mice could not fully foster the development of follicular B helper T (Tfh) cells even after immunization with foreign antigens. Further experiments indicated that Alox5 affected mortality in experimentally induced enterocolitis in germ-prone circumstances, indicating that Alox5 would endow immunologic milieu. Our results illustrate the novel role of Alox5 in adaptive humoral immunity by managing primary B cells and Tfh cells in vivo.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
|
| pubmed:issn |
1525-2191
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| pubmed:author |
pubmed-author:AraShihokoS,
pubmed-author:HatateChizuruC,
pubmed-author:HimiTetsuoT,
pubmed-author:HiroseBungoB,
pubmed-author:IchimiyaShingoS,
pubmed-author:IzumiTakashiT,
pubmed-author:KikuchiTomokiT,
pubmed-author:KoshibaShigeruS,
pubmed-author:KuboTerufumiT,
pubmed-author:MatsumiyaHiroshiH,
pubmed-author:NagashimaTsutomuT,
pubmed-author:SaitoYoshiyukiY,
pubmed-author:SatoNoriyukiN,
pubmed-author:ShirasakiHideakiH,
pubmed-author:TakamiTsuyoshiT,
pubmed-author:TonookaAkikoA,
pubmed-author:YeRui CarrieRC,
pubmed-author:ZhangJunJ
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| pubmed:copyrightInfo |
Copyright © 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
178
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
222-32
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| pubmed:meshHeading |
pubmed-meshheading:21224059-Adaptive Immunity,
pubmed-meshheading:21224059-Amino Acid Sequence,
pubmed-meshheading:21224059-Animals,
pubmed-meshheading:21224059-Arachidonate 5-Lipoxygenase,
pubmed-meshheading:21224059-B-Lymphocytes,
pubmed-meshheading:21224059-Cell Line, Tumor,
pubmed-meshheading:21224059-Enterocolitis,
pubmed-meshheading:21224059-Homeodomain Proteins,
pubmed-meshheading:21224059-Humans,
pubmed-meshheading:21224059-Immunity, Humoral,
pubmed-meshheading:21224059-Lymphoma, Mantle-Cell,
pubmed-meshheading:21224059-Mice,
pubmed-meshheading:21224059-Mice, Mutant Strains,
pubmed-meshheading:21224059-Molecular Sequence Data,
pubmed-meshheading:21224059-T-Lymphocytes, Helper-Inducer
|
| pubmed:year |
2011
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| pubmed:articleTitle |
Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help.
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| pubmed:affiliation |
Department of Pathology Sapporo Medical University School of Medicine, Sapporo, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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