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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0027651,
umls-concept:C0030705,
umls-concept:C0036525,
umls-concept:C0681842,
umls-concept:C0871261,
umls-concept:C0995188,
umls-concept:C1522484,
umls-concept:C1527249,
umls-concept:C1537502,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
3
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pubmed:dateCreated |
2011-2-2
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pubmed:abstractText |
Although it is accepted that metastatic colorectal cancers (mCRCs) that carry activating mutations in KRAS are unresponsive to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, a significant fraction of KRAS wild-type (wt) mCRCs are also unresponsive to anti-EGFR therapy. Genes encoding EGFR ligands amphiregulin (AREG) and epiregulin (EREG) are promising gene expression-based markers but have not been incorporated into a test to dichotomise KRAS wt mCRC patients with respect to sensitivity to anti-EGFR treatment.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-11097226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-11531254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-12098689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-14993230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-15269313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-15625347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-15677698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-15677699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-15753456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-15863375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-16024606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-17363584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-17375050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-17664471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-17697383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-17974556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-17998284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-18202412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-18316791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-18621636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-18669866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-18794099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-18946061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-19001320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-19002188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-19188670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-19223544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-19240792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-19366826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-19603018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-19603024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-19738126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-19826350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21206494-19846928
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1532-1827
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pubmed:author |
pubmed-author:BakerJ BJB,
pubmed-author:ClarkE AEA,
pubmed-author:DuttaDD,
pubmed-author:HarbisonC TCT,
pubmed-author:Khambata-FordSS,
pubmed-author:LiL TLT,
pubmed-author:MaddaloFF,
pubmed-author:MauroD JDJ,
pubmed-author:MunnekeB MBM,
pubmed-author:RowinskyE KEK,
pubmed-author:ShahPP,
pubmed-author:WatsonDD
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
488-95
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pubmed:dateRevised |
2011-7-26
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pubmed:meshHeading |
|
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pubmed:year |
2011
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pubmed:articleTitle |
Tumour gene expression predicts response to cetuximab in patients with KRAS wild-type metastatic colorectal cancer.
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pubmed:affiliation |
Genomic Health, Inc., 301 Penobscot Drive, Redwood City, CA, USA.
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pubmed:publicationType |
Journal Article
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