| pubmed-article:2117396 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2117396 | lifeskim:mentions | umls-concept:C0887913 | lld:lifeskim |
| pubmed-article:2117396 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:2117396 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:2117396 | lifeskim:mentions | umls-concept:C0024204 | lld:lifeskim |
| pubmed-article:2117396 | lifeskim:mentions | umls-concept:C0242245 | lld:lifeskim |
| pubmed-article:2117396 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:2117396 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:2117396 | lifeskim:mentions | umls-concept:C0085973 | lld:lifeskim |
| pubmed-article:2117396 | lifeskim:mentions | umls-concept:C0007320 | lld:lifeskim |
| pubmed-article:2117396 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:2117396 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2117396 | pubmed:dateCreated | 1990-9-17 | lld:pubmed |
| pubmed-article:2117396 | pubmed:abstractText | Follicular dendritic cells (FDC) from axillary lymphoid tissue of a patient with acquired immune deficiency syndrome (AIDS) were analyzed for the presence of gag and env proteins and env mRNA of human immunodeficiency virus type-1 (HIV-1), both in a purified FDC suspension and on frozen sections. Isolated cells with morphologic and immunocytochemical features of FDC expressed HIV-1 core (gag) proteins p15, p17, p24, and envelope (env) protein gp41; in addition HIV-1 env mRNA was detected in some of these cells. This corresponded with intense expression of HIV-1 proteins by FDC in germinal centers in situ, and the presence of HIV-1 mRNA-positive cells in germinal follicles. These findings led us to conclude that FDC are infected and able to produce HIV-1. Such infection may contribute significantly to the destruction of the FDC network during the lymphadenopathy phase after HIV-1 infection. | lld:pubmed |
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| pubmed-article:2117396 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2117396 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2117396 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2117396 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2117396 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2117396 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:2117396 | pubmed:author | pubmed-author:SchuurmanH... | lld:pubmed |
| pubmed-article:2117396 | pubmed:author | pubmed-author:GoudsmitJJ | lld:pubmed |
| pubmed-article:2117396 | pubmed:author | pubmed-author:ParmentierH... | lld:pubmed |
| pubmed-article:2117396 | pubmed:author | pubmed-author:BorleffsJ CJC | lld:pubmed |
| pubmed-article:2117396 | pubmed:author | pubmed-author:van WichenDD | lld:pubmed |
| pubmed-article:2117396 | pubmed:author | pubmed-author:Sie-GoD MDM | lld:pubmed |
| pubmed-article:2117396 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2117396 | pubmed:volume | 137 | lld:pubmed |
| pubmed-article:2117396 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2117396 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2117396 | pubmed:pagination | 247-51 | lld:pubmed |
| pubmed-article:2117396 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2117396 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2117396 | pubmed:articleTitle | HIV-1 infection and virus production in follicular dendritic cells in lymph nodes. A case report, with analysis of isolated follicular dendritic cells. | lld:pubmed |
| pubmed-article:2117396 | pubmed:affiliation | Department of Internal Medicine, University Hospital, Utrecht, The Netherlands. | lld:pubmed |
| pubmed-article:2117396 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2117396 | pubmed:publicationType | Case Reports | lld:pubmed |
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