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rdf:type |
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lifeskim:mentions |
umls-concept:C0086418,
umls-concept:C0205263,
umls-concept:C0221928,
umls-concept:C0225336,
umls-concept:C0812246,
umls-concept:C0871261,
umls-concept:C1171318,
umls-concept:C1334481,
umls-concept:C1416660,
umls-concept:C1442512,
umls-concept:C1456820,
umls-concept:C1515877,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1879547,
umls-concept:C2911692
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pubmed:issue |
2
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pubmed:dateCreated |
2011-2-7
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pubmed:abstractText |
ECs lining arteries respond to LSS by suppressing pro-inflammatory changes, in part through the activation of MEK5, ERK5 and induction of KLF4. We examined if this anti-inflammatory pathway operates in human ECs lining microvessels, the principal site of inflammatory responses.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/GKLF protein,
http://linkedlifedata.com/resource/pubmed/chemical/Kruppel-Like Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 5,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 7,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1549-8719
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pubmed:author |
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pubmed:copyrightInfo |
© 2011 John Wiley & Sons Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
102-17
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pubmed:meshHeading |
pubmed-meshheading:21166929-Base Sequence,
pubmed-meshheading:21166929-Cells, Cultured,
pubmed-meshheading:21166929-Endothelial Cells,
pubmed-meshheading:21166929-Enzyme Activation,
pubmed-meshheading:21166929-Gene Expression Profiling,
pubmed-meshheading:21166929-Gene Knockdown Techniques,
pubmed-meshheading:21166929-Humans,
pubmed-meshheading:21166929-Kruppel-Like Transcription Factors,
pubmed-meshheading:21166929-MAP Kinase Kinase 5,
pubmed-meshheading:21166929-Mitogen-Activated Protein Kinase 7,
pubmed-meshheading:21166929-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:21166929-RNA, Messenger,
pubmed-meshheading:21166929-RNA, Small Interfering,
pubmed-meshheading:21166929-Shear Strength,
pubmed-meshheading:21166929-Stress, Mechanical,
pubmed-meshheading:21166929-Tumor Necrosis Factor-alpha
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pubmed:year |
2011
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pubmed:articleTitle |
MEK5 is activated by shear stress, activates ERK5 and induces KLF4 to modulate TNF responses in human dermal microvascular endothelial cells.
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pubmed:affiliation |
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8089, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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