Linked Life Data

21161310

Source:http://linkedlifedata.com/resource/pubmed/id/21161310

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-4-1
pubmed:abstractText
The efficacy of intense pulsed light (IPL) in remodeling the extracellular matrix of aged skin had been proven by an increasing number of clinical trials. However, because of the lack of research about the underlying molecular and signaling mechanisms, its efficiency had not been accepted universally. A potential mechanism of IPL rejuvenation effects is due to its different effects on diverse cytokines, the impact of IPL on them may determine the phenotype and prognosis of the aged skin. We designed this study to evaluate the impact of IPL on the secretion of matrix metalloproteinase-1 (MMP-1), transforming growth factor-?1 (TGF-?1), and the mitogen-activated protein kinase (MAPK) signaling pathway in human skin fibroblasts, and tried to study the respective functions of MAPKs as mediators of the MMP-1, TGF-?1 secretion. Results showed that the MMP-1 secretion was only enhanced by IPL at 10 J/cm(2); while the TGF-?1 secretion was inhibited by IPL when the fluence was below 36 J/cm(2), but enhanced at 72 J/cm(2). Meanwhile, ERK inhibitor PD98059 decreased MMP-1 secretion, but did not show a significant influence on TGF-?1; JNK inhibitor SP600125 increased the secretion of MMP-1 and decreased the TGF-?1 secretion; P38 inhibitor SB203580 had no significant influence on MMP-1 but increased the secretion of TGF-?1. Our findings indicated that the bidirectional influence of IPL on the secretion of MMP-1 and TGF-?1 is a potential mechanism of its skin rejuvenation effect; and the secretion of these two cytokines can be mediated by MAPKs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1435-604X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
381-7
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
IPL irradiation rejuvenates skin collagen via the bidirectional regulation of MMP-1 and TGF-?1 mediated by MAPKs in fibroblasts.
pubmed:affiliation
Department of Dermatology, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan Province, People's Republic of China. dermalhjh@yahoo.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Evaluation Studies