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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-2-17
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pubmed:abstractText |
In calcific aortic valve disease, myofibroblasts and activation of the transforming growth factor-?1 (TGF-?1) and Wnt/?-catenin pathways are observed in the fibrosa, the stiffer layer of the leaflet, but their association is unknown. We elucidated the roles of ?-catenin and extracellular matrix stiffness in TGF-?1-induced myofibroblast differentiation of valve interstitial cells (VICs).
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transforming Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad3 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/TGF-beta type I receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt3 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
590-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21127288-Active Transport, Cell Nucleus,
pubmed-meshheading:21127288-Animals,
pubmed-meshheading:21127288-Aortic Valve,
pubmed-meshheading:21127288-Cell Transdifferentiation,
pubmed-meshheading:21127288-Cells, Cultured,
pubmed-meshheading:21127288-Collagen,
pubmed-meshheading:21127288-Disease Models, Animal,
pubmed-meshheading:21127288-Elasticity,
pubmed-meshheading:21127288-Extracellular Matrix,
pubmed-meshheading:21127288-Heart Valve Diseases,
pubmed-meshheading:21127288-Myofibroblasts,
pubmed-meshheading:21127288-Phosphorylation,
pubmed-meshheading:21127288-Protein-Serine-Threonine Kinases,
pubmed-meshheading:21127288-RNA Interference,
pubmed-meshheading:21127288-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:21127288-Sclerosis,
pubmed-meshheading:21127288-Signal Transduction,
pubmed-meshheading:21127288-Smad2 Protein,
pubmed-meshheading:21127288-Smad3 Protein,
pubmed-meshheading:21127288-Swine,
pubmed-meshheading:21127288-Time Factors,
pubmed-meshheading:21127288-Transforming Growth Factor beta1,
pubmed-meshheading:21127288-Wnt Proteins,
pubmed-meshheading:21127288-Wnt3 Protein,
pubmed-meshheading:21127288-beta Catenin
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pubmed:year |
2011
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pubmed:articleTitle |
?-catenin mediates mechanically regulated, transforming growth factor-?1-induced myofibroblast differentiation of aortic valve interstitial cells.
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pubmed:affiliation |
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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