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rdf:type |
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lifeskim:mentions |
umls-concept:C0002085,
umls-concept:C0012854,
umls-concept:C0205314,
umls-concept:C0332256,
umls-concept:C0475358,
umls-concept:C0521115,
umls-concept:C0544886,
umls-concept:C0679622,
umls-concept:C0681504,
umls-concept:C0812241,
umls-concept:C1335212,
umls-concept:C1414313,
umls-concept:C1511790,
umls-concept:C1537502,
umls-concept:C1710360
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pubmed:issue |
2
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pubmed:dateCreated |
2011-2-23
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pubmed:abstractText |
DNA somatic mutations of EGFR, KRAS, BRAF and PIK3CA in the epidermal growth factor receptor (EGFR) signaling pathway play critical roles in the response or resistance of tumors to targeted therapy with tyrosine kinase inhibitors (EGFR-TKIs). To provide a high-throughput (HTP) clinical testing service for detecting these mutations, we developed a novel platform, SurPlex®-xTAG70plex-EGFR liquidchip.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BRAF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/EGFR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Formaldehyde,
http://linkedlifedata.com/resource/pubmed/chemical/KRAS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PIK3CA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins B-raf,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1434-6621
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pubmed:author |
pubmed-author:HeJiayingJ,
pubmed-author:LiGuoqiangG,
pubmed-author:LiuZhimingZ,
pubmed-author:LuoXiaodiX,
pubmed-author:QinHuijuanH,
pubmed-author:Ren-HeidenreichLifenL,
pubmed-author:WuShiyangS,
pubmed-author:XuJiasenJ,
pubmed-author:YuGangG,
pubmed-author:ZengTaoT,
pubmed-author:ZhuZeyaoZ
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
191-5
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pubmed:meshHeading |
pubmed-meshheading:21118047-Alleles,
pubmed-meshheading:21118047-DNA Mutational Analysis,
pubmed-meshheading:21118047-Formaldehyde,
pubmed-meshheading:21118047-Humans,
pubmed-meshheading:21118047-Mutation,
pubmed-meshheading:21118047-Neoplasms,
pubmed-meshheading:21118047-Paraffin Embedding,
pubmed-meshheading:21118047-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:21118047-Proto-Oncogene Proteins,
pubmed-meshheading:21118047-Proto-Oncogene Proteins B-raf,
pubmed-meshheading:21118047-Receptor, Epidermal Growth Factor,
pubmed-meshheading:21118047-Time Factors,
pubmed-meshheading:21118047-Tissue Fixation,
pubmed-meshheading:21118047-ras Proteins
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pubmed:year |
2011
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pubmed:articleTitle |
A novel liquidchip platform for simultaneous detection of 70 alleles of DNA somatic mutations on EGFR, KRAS, BRAF and PIK3CA from formalin-fixed and paraffin-embedded slides containing tumor tissue.
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pubmed:affiliation |
SurExam Bio-Tech Co. Ltd., Guangzhou Technology Innovation Base, Science City, Guangzhou, PR China.
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pubmed:publicationType |
Journal Article
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