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pubmed-article:21091277pubmed:abstractTextThe ABCG2 efflux transporter is expressed in multiple tissues and plays an important role in the disposition of many statins. The functional 421C>A polymorphism in ABCG2 that reduces transporter activity has been found to be associated with increased systemic exposures to certain statins.lld:pubmed
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pubmed-article:21091277pubmed:articleTitleThe ABCG2 transporter and its relations with the pharmacokinetics, drug interaction and lipid-lowering effects of statins.lld:pubmed
pubmed-article:21091277pubmed:affiliationThe Chinese University of Hong Kong, Prince of Wales Hospital, Department of Medicine and Therapeutics, Shatin, Hong Kong SAR.lld:pubmed
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