| pubmed-article:21085119 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21085119 | lifeskim:mentions | umls-concept:C0228065 | lld:lifeskim |
| pubmed-article:21085119 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
| pubmed-article:21085119 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:21085119 | pubmed:issue | 7324 | lld:pubmed |
| pubmed-article:21085119 | pubmed:dateCreated | 2010-12-2 | lld:pubmed |
| pubmed-article:21085119 | pubmed:abstractText | The odour of acids has a distinct quality that is perceived as sharp, pungent and often irritating. How acidity is sensed and translated into an appropriate behavioural response is poorly understood. Here we describe a functionally segregated population of olfactory sensory neurons in the fruitfly, Drosophila melanogaster, that are highly selective for acidity. These olfactory sensory neurons express IR64a, a member of the recently identified ionotropic receptor (IR) family of putative olfactory receptors. In vivo calcium imaging showed that IR64a+ neurons projecting to the DC4 glomerulus in the antennal lobe are specifically activated by acids. Flies in which the function of IR64a+ neurons or the IR64a gene is disrupted had defects in acid-evoked physiological and behavioural responses, but their responses to non-acidic odorants remained unaffected. Furthermore, artificial stimulation of IR64a+ neurons elicited avoidance responses. Taken together, these results identify cellular and molecular substrates for acid detection in the Drosophila olfactory system and support a labelled-line mode of acidity coding at the periphery. | lld:pubmed |
| pubmed-article:21085119 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21085119 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21085119 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21085119 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21085119 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:21085119 | pubmed:issn | 1476-4687 | lld:pubmed |
| pubmed-article:21085119 | pubmed:author | pubmed-author:SuhGreg S BGS | lld:pubmed |
| pubmed-article:21085119 | pubmed:author | pubmed-author:BentonRichard... | lld:pubmed |
| pubmed-article:21085119 | pubmed:author | pubmed-author:MinSoohongS | lld:pubmed |
| pubmed-article:21085119 | pubmed:author | pubmed-author:GrosjeanYaelY | lld:pubmed |
| pubmed-article:21085119 | pubmed:author | pubmed-author:AiMinrongM | lld:pubmed |
| pubmed-article:21085119 | pubmed:author | pubmed-author:LeblancCharlo... | lld:pubmed |
| pubmed-article:21085119 | pubmed:author | pubmed-author:BellRatiR | lld:pubmed |
| pubmed-article:21085119 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21085119 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:21085119 | pubmed:volume | 468 | lld:pubmed |
| pubmed-article:21085119 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21085119 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21085119 | pubmed:pagination | 691-5 | lld:pubmed |
| pubmed-article:21085119 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
| pubmed-article:21085119 | pubmed:meshHeading | pubmed-meshheading:21085119... | lld:pubmed |
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| pubmed-article:21085119 | pubmed:meshHeading | pubmed-meshheading:21085119... | lld:pubmed |
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| pubmed-article:21085119 | pubmed:meshHeading | pubmed-meshheading:21085119... | lld:pubmed |
| pubmed-article:21085119 | pubmed:meshHeading | pubmed-meshheading:21085119... | lld:pubmed |
| pubmed-article:21085119 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21085119 | pubmed:articleTitle | Acid sensing by the Drosophila olfactory system. | lld:pubmed |
| pubmed-article:21085119 | pubmed:affiliation | Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University, School of Medicine, New York, New York 10016, USA. | lld:pubmed |
| pubmed-article:21085119 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21085119 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21085119 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:33251 | entrezgene:pubmed | pubmed-article:21085119 | lld:entrezgene |
| entrez-gene:38453 | entrezgene:pubmed | pubmed-article:21085119 | lld:entrezgene |
| entrez-gene:38616 | entrezgene:pubmed | pubmed-article:21085119 | lld:entrezgene |
| entrez-gene:45928 | entrezgene:pubmed | pubmed-article:21085119 | lld:entrezgene |
