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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7324
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pubmed:dateCreated |
2010-12-2
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pubmed:abstractText |
The odour of acids has a distinct quality that is perceived as sharp, pungent and often irritating. How acidity is sensed and translated into an appropriate behavioural response is poorly understood. Here we describe a functionally segregated population of olfactory sensory neurons in the fruitfly, Drosophila melanogaster, that are highly selective for acidity. These olfactory sensory neurons express IR64a, a member of the recently identified ionotropic receptor (IR) family of putative olfactory receptors. In vivo calcium imaging showed that IR64a+ neurons projecting to the DC4 glomerulus in the antennal lobe are specifically activated by acids. Flies in which the function of IR64a+ neurons or the IR64a gene is disrupted had defects in acid-evoked physiological and behavioural responses, but their responses to non-acidic odorants remained unaffected. Furthermore, artificial stimulation of IR64a+ neurons elicited avoidance responses. Taken together, these results identify cellular and molecular substrates for acid detection in the Drosophila olfactory system and support a labelled-line mode of acidity coding at the periphery.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-10923676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-10943836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-11175727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-11291099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-12408848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-12553914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-15303329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-15339651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-15372051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-15972463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-16139208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-16809465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-16929298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-17167414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-17360684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-19135896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-19171076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-19279637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-19541615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-19945383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-5417711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-7134974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-7857643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-8197129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085119-8565054
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1476-4687
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
2
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pubmed:volume |
468
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
691-5
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pubmed:dateRevised |
2011-7-28
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pubmed:meshHeading |
pubmed-meshheading:21085119-Acetic Acid,
pubmed-meshheading:21085119-Acids,
pubmed-meshheading:21085119-Animals,
pubmed-meshheading:21085119-Arthropod Antennae,
pubmed-meshheading:21085119-Calcium Signaling,
pubmed-meshheading:21085119-Carbon Dioxide,
pubmed-meshheading:21085119-Carbonic Acid,
pubmed-meshheading:21085119-Drosophila Proteins,
pubmed-meshheading:21085119-Drosophila melanogaster,
pubmed-meshheading:21085119-Maze Learning,
pubmed-meshheading:21085119-Odors,
pubmed-meshheading:21085119-Olfactory Pathways,
pubmed-meshheading:21085119-Receptors, Ionotropic Glutamate,
pubmed-meshheading:21085119-Receptors, Odorant,
pubmed-meshheading:21085119-Sensilla,
pubmed-meshheading:21085119-Sensory Receptor Cells,
pubmed-meshheading:21085119-Temperature
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pubmed:year |
2010
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pubmed:articleTitle |
Acid sensing by the Drosophila olfactory system.
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pubmed:affiliation |
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University, School of Medicine, New York, New York 10016, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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