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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2011-3-11
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pubmed:abstractText |
Autoimmune lymphoproliferative syndrome (ALPS) is classically defined as a disease with defective FAS-mediated apoptosis (type I-III). Germline NRAS mutation was recently identified in type IV ALPS. We report 2 cases with ALPS-like disease with somatic KRAS mutation. Both cases were characterized by prominent autoimmune cytopenia and lymphoadenopathy/splenomegaly. These patients did not satisfy the diagnostic criteria for ALPS or juvenile myelomonocytic leukemia and are probably defined as a new disease entity of RAS-associated ALPS-like disease (RALD).
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1528-0020
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pubmed:author |
pubmed-author:DoisakiSayokoS,
pubmed-author:KasaharaYoshihitoY,
pubmed-author:KoikeKenichiK,
pubmed-author:KojimaSeijiS,
pubmed-author:MatsudaKazuyukiK,
pubmed-author:MitsuikiNorikoN,
pubmed-author:MizutaniShukiS,
pubmed-author:MorioTomohiroT,
pubmed-author:MuramatsuHidekiH,
pubmed-author:NagasawaMasayukiM,
pubmed-author:PiaoJinhuaJ,
pubmed-author:ShinodaKunihiroK,
pubmed-author:TakagiMariM,
pubmed-author:TakagiMasatoshiM,
pubmed-author:TakaoAkiraA
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
117
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
2887-90
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pubmed:meshHeading |
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pubmed:year |
2011
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pubmed:articleTitle |
Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation.
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pubmed:affiliation |
Department of Pediatrics and Developmental Biology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan. m.takagi.ped@tmd.ac.jp
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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