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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-11-24
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pubmed:abstractText |
In male Drosophila melanogaster, the male specific lethal (MSL) complex is somehow responsible for a two-fold increase in transcription of most X-linked genes, which are enriched for histone H4 acetylated at lysine 16 (H4K16ac). This acetylation requires MOF, a histone acetyltransferase that is a component of the MSL complex. MOF also associates with the non-specific lethal or NSL complex. The MSL complex is bound within active genes on the male X chromosome with a 3' bias. In contrast, the NSL complex is enriched at promoter regions of many autosomal and X-linked genes in both sexes. In this study we have investigated the role of MOF as a transcriptional activator.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GAL4 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/mof protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2199
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
80
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pubmed:meshHeading |
pubmed-meshheading:21062452-Acetylation,
pubmed-meshheading:21062452-Amino Acid Sequence,
pubmed-meshheading:21062452-Animals,
pubmed-meshheading:21062452-DNA-Binding Proteins,
pubmed-meshheading:21062452-Drosophila,
pubmed-meshheading:21062452-Drosophila Proteins,
pubmed-meshheading:21062452-Female,
pubmed-meshheading:21062452-Genes, Reporter,
pubmed-meshheading:21062452-Genes, X-Linked,
pubmed-meshheading:21062452-Histone Acetyltransferases,
pubmed-meshheading:21062452-Histones,
pubmed-meshheading:21062452-Male,
pubmed-meshheading:21062452-Models, Molecular,
pubmed-meshheading:21062452-Molecular Sequence Data,
pubmed-meshheading:21062452-Nuclear Proteins,
pubmed-meshheading:21062452-Polytene Chromosome,
pubmed-meshheading:21062452-Recombinant Fusion Proteins,
pubmed-meshheading:21062452-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:21062452-Sequence Alignment,
pubmed-meshheading:21062452-Sex Factors,
pubmed-meshheading:21062452-Transcription Factors,
pubmed-meshheading:21062452-Transcriptional Activation
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pubmed:year |
2010
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pubmed:articleTitle |
Sex-biased transcription enhancement by a 5' tethered Gal4-MOF histone acetyltransferase fusion protein in Drosophila.
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pubmed:affiliation |
Institute of Molecular BioSciences, Massey University, Private Bag 11222, Palmerston North, New Zealand.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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