Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2010-11-18
pubmed:databankReference
pubmed:abstractText
In China, 5 patients with acute flaccid paralysis (AFP) associated with type 2 vaccine-derived poliovirus (VDPV) were identified by an AFP surveillance system from 1996 through 2009. A maximum-likelihood tree shows that all 5 Chinese VDPVs were independent. These 5 VDPVs were 100-216 d old according to the number of synonymous substitutions per synonymous site and 176-292 d old according to the number of substitutions per site. This result indicates limited virus replication since the administration of the initiating oral polio vaccine (OPV) dose, which is consistent with the rapid evolution rate of poliovirus genomes. The above-mentioned VDPVs have important implications in the global polio eradication initiative. Localized, limited, and transient circulation may be typical of OPVs; hence, independent VDPVs could be found because of the large population and excellent surveillance system, which permitted early detection and response, but sustained transmission was limited because of high population immunity.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1537-6613
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
202
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1780-8
pubmed:dateRevised
2011-7-13
pubmed:meshHeading
pubmed-meshheading:21050127-Adolescent, pubmed-meshheading:21050127-Child, pubmed-meshheading:21050127-Child, Preschool, pubmed-meshheading:21050127-China, pubmed-meshheading:21050127-Cluster Analysis, pubmed-meshheading:21050127-Female, pubmed-meshheading:21050127-Humans, pubmed-meshheading:21050127-Immunization, pubmed-meshheading:21050127-Infant, pubmed-meshheading:21050127-Male, pubmed-meshheading:21050127-Molecular Epidemiology, pubmed-meshheading:21050127-Molecular Sequence Data, pubmed-meshheading:21050127-Phylogeny, pubmed-meshheading:21050127-Point Mutation, pubmed-meshheading:21050127-Poliomyelitis, pubmed-meshheading:21050127-Poliovirus, pubmed-meshheading:21050127-Poliovirus Vaccine, Oral, pubmed-meshheading:21050127-Prevalence, pubmed-meshheading:21050127-RNA, Viral, pubmed-meshheading:21050127-Sequence Analysis, DNA, pubmed-meshheading:21050127-Sequence Homology
pubmed:year
2010
pubmed:articleTitle
Type 2 vaccine-derived poliovirus from patients with acute flaccid paralysis in china: current immunization strategy effectively prevented its sustained transmission.
pubmed:affiliation
World Health Organization Western Pacific Regional Polio Reference Laboratory and State Key Laboratory for Molecular Virology and Genetic Engineering, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't