| pubmed-article:2104745 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2104745 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:2104745 | lifeskim:mentions | umls-concept:C0006434 | lld:lifeskim |
| pubmed-article:2104745 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2104745 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:2104745 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:2104745 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:2104745 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:2104745 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2104745 | pubmed:dateCreated | 1990-2-6 | lld:pubmed |
| pubmed-article:2104745 | pubmed:abstractText | Tumor necrosis factor alpha (TNF-alpha)/cachectin is a monocyte/macrophage-derived cytokine implicated as a proximal mediator of many of the catastrophic host responses to infection or endotoxin. However, circulating levels of TNF-alpha/cachectin have only been episodically detected in hospitalized patients with life-threatening bacterial infections. In the present report, increased quantities of immune-reactive TNF-alpha/cachectin were recovered from the livers of rats 3 days following a lethal burn and infection. Two species of TNF-alpha/cachectin were detected, one of approximately 29 kd and the other 17 kd, as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. In murine peritoneal macrophages and rat Kupffer cells stimulated in vitro with endotoxin, a 29-kd cell-associated and 17-kd secreted form were also detected. We conclude that the increased appearance in vivo of a 29-kd form of TNF-alpha/cachectin from the livers of lethally burned and infected rats represents a novel cell-associated form of the protein. | lld:pubmed |
| pubmed-article:2104745 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2104745 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2104745 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2104745 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2104745 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2104745 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2104745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2104745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2104745 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2104745 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2104745 | pubmed:issn | 0004-0010 | lld:pubmed |
| pubmed-article:2104745 | pubmed:author | pubmed-author:BarbeeRR | lld:pubmed |
| pubmed-article:2104745 | pubmed:author | pubmed-author:LowryS FSF | lld:pubmed |
| pubmed-article:2104745 | pubmed:author | pubmed-author:HOMM | lld:pubmed |
| pubmed-article:2104745 | pubmed:author | pubmed-author:MoldawerL LLL | lld:pubmed |
| pubmed-article:2104745 | pubmed:author | pubmed-author:KeoghCC | lld:pubmed |
| pubmed-article:2104745 | pubmed:author | pubmed-author:FontTT | lld:pubmed |
| pubmed-article:2104745 | pubmed:author | pubmed-author:MineiJ PJP | lld:pubmed |
| pubmed-article:2104745 | pubmed:author | pubmed-author:FelsenDD | lld:pubmed |
| pubmed-article:2104745 | pubmed:author | pubmed-author:MarcoeK FKF | lld:pubmed |
| pubmed-article:2104745 | pubmed:author | pubmed-author:SeniukSS | lld:pubmed |
| pubmed-article:2104745 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2104745 | pubmed:volume | 125 | lld:pubmed |
| pubmed-article:2104745 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2104745 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2104745 | pubmed:pagination | 79-84; discussion 85 | lld:pubmed |
| pubmed-article:2104745 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2104745 | pubmed:meshHeading | pubmed-meshheading:2104745-... | lld:pubmed |
| pubmed-article:2104745 | pubmed:meshHeading | pubmed-meshheading:2104745-... | lld:pubmed |
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| pubmed-article:2104745 | pubmed:meshHeading | pubmed-meshheading:2104745-... | lld:pubmed |
| pubmed-article:2104745 | pubmed:meshHeading | pubmed-meshheading:2104745-... | lld:pubmed |
| pubmed-article:2104745 | pubmed:meshHeading | pubmed-meshheading:2104745-... | lld:pubmed |
| pubmed-article:2104745 | pubmed:meshHeading | pubmed-meshheading:2104745-... | lld:pubmed |
| pubmed-article:2104745 | pubmed:meshHeading | pubmed-meshheading:2104745-... | lld:pubmed |
| pubmed-article:2104745 | pubmed:meshHeading | pubmed-meshheading:2104745-... | lld:pubmed |
| pubmed-article:2104745 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2104745 | pubmed:articleTitle | Identification of a novel tumor necrosis factor alpha/cachectin from the livers of burned and infected rats. | lld:pubmed |
| pubmed-article:2104745 | pubmed:affiliation | Laboratory of Surgical Metabolism, New York, Hospital-Cornell University Medical College, NY 10021. | lld:pubmed |
| pubmed-article:2104745 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2104745 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2104745 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2104745 | lld:pubmed |
