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pubmed-article:21041086pubmed:abstractTextThe iron-ion catalyzed oxidation of the ethanol solution of rosmarinic acid, a potent antioxidant polyphenol of Lamiaceae (Labiatae) plants, afforded a highly tyrosinase-inhibitory active product. The structure of the active product in the oxidation product mixture was determined using extensive NMR spectroscopy to have a novel oxygen-containing seven-membered ring system. The formation mechanism of the unique ring structure from the catechol part of the rosmarinic acid was proposed.lld:pubmed
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pubmed-article:21041086pubmed:copyrightInfoCopyright © 2010 Elsevier Ltd. All rights reserved.lld:pubmed
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pubmed-article:21041086pubmed:articleTitleA novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antioxidative Lamiaceae polyphenol.lld:pubmed
pubmed-article:21041086pubmed:affiliationGraduate School of Integrated Arts and Sciences, University of Tokushima, Tokushima, Japan.lld:pubmed
pubmed-article:21041086pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21041086pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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