rdf:type |
|
lifeskim:mentions |
umls-concept:C0021469,
umls-concept:C0030011,
umls-concept:C0041484,
umls-concept:C0071649,
umls-concept:C0073590,
umls-concept:C0205314,
umls-concept:C0439858,
umls-concept:C0441655,
umls-concept:C0443177,
umls-concept:C0524904,
umls-concept:C0679622,
umls-concept:C1514468,
umls-concept:C2349975
|
pubmed:issue |
24
|
pubmed:dateCreated |
2010-11-24
|
pubmed:abstractText |
The iron-ion catalyzed oxidation of the ethanol solution of rosmarinic acid, a potent antioxidant polyphenol of Lamiaceae (Labiatae) plants, afforded a highly tyrosinase-inhibitory active product. The structure of the active product in the oxidation product mixture was determined using extensive NMR spectroscopy to have a novel oxygen-containing seven-membered ring system. The formation mechanism of the unique ring structure from the catechol part of the rosmarinic acid was proposed.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Catechols,
http://linkedlifedata.com/resource/pubmed/chemical/Cinnamates,
http://linkedlifedata.com/resource/pubmed/chemical/Depsides,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Iron,
http://linkedlifedata.com/resource/pubmed/chemical/Monophenol Monooxygenase,
http://linkedlifedata.com/resource/pubmed/chemical/Phenols,
http://linkedlifedata.com/resource/pubmed/chemical/Polyphenols,
http://linkedlifedata.com/resource/pubmed/chemical/catechol,
http://linkedlifedata.com/resource/pubmed/chemical/rosmarinic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
|
pubmed:issn |
1464-3405
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pubmed:author |
|
pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
|
pubmed:volume |
20
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
7393-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21041086-Antioxidants,
pubmed-meshheading:21041086-Catalysis,
pubmed-meshheading:21041086-Catechols,
pubmed-meshheading:21041086-Cinnamates,
pubmed-meshheading:21041086-Depsides,
pubmed-meshheading:21041086-Enzyme Inhibitors,
pubmed-meshheading:21041086-Flavonoids,
pubmed-meshheading:21041086-Iron,
pubmed-meshheading:21041086-Lamiaceae,
pubmed-meshheading:21041086-Magnetic Resonance Spectroscopy,
pubmed-meshheading:21041086-Molecular Conformation,
pubmed-meshheading:21041086-Monophenol Monooxygenase,
pubmed-meshheading:21041086-Oxidation-Reduction,
pubmed-meshheading:21041086-Phenols,
pubmed-meshheading:21041086-Polyphenols
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pubmed:year |
2010
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pubmed:articleTitle |
A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antioxidative Lamiaceae polyphenol.
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pubmed:affiliation |
Graduate School of Integrated Arts and Sciences, University of Tokushima, Tokushima, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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