| pubmed-article:21035159 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:21035159 | lifeskim:mentions | umls-concept:C0015859 | lld:lifeskim |
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| pubmed-article:21035159 | lifeskim:mentions | umls-concept:C0441471 | lld:lifeskim |
| pubmed-article:21035159 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:21035159 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:21035159 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:21035159 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:21035159 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:21035159 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:21035159 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:21035159 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:21035159 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:21035159 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21035159 | pubmed:dateCreated | 2010-11-29 | lld:pubmed |
| pubmed-article:21035159 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:abstractText | Type I interferons (IFNs) are essential to the clearance of viral diseases, however, a clear distinction between genes upregulated by direct virus-cell interactions and genes upregulated by secondary IFN production has not been made. Here, we investigated differential gene regulation in ferrets upon subcutaneous administration of IFN-?2b and during SARS-CoV infection. In vivo experiments revealed that IFN-?2b causes STAT1 phosphorylation and upregulation of abundant IFN response genes (IRGs), chemokine receptors, and other genes that participate in phagocytosis and leukocyte transendothelial migration. During infection with SARS-CoV not only a variety of IRGs were upregulated, but also a significantly broader range of genes involved in cell migration and inflammation. This work allowed dissection of several molecular signatures present during SARS-CoV which are part of a robust IFN antiviral response. These signatures can be useful markers to evaluate the status of IFN responses during a viral infection and specific features of different viruses. | lld:pubmed |
| pubmed-article:21035159 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21035159 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21035159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21035159 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21035159 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:21035159 | pubmed:issn | 1096-0341 | lld:pubmed |
| pubmed-article:21035159 | pubmed:author | pubmed-author:DevoeGG | lld:pubmed |
| pubmed-article:21035159 | pubmed:author | pubmed-author:GuanYiY | lld:pubmed |
| pubmed-article:21035159 | pubmed:author | pubmed-author:ChenHonglinH | lld:pubmed |
| pubmed-article:21035159 | pubmed:author | pubmed-author:JonssonCollee... | lld:pubmed |
| pubmed-article:21035159 | pubmed:author | pubmed-author:RoweThomasT | lld:pubmed |
| pubmed-article:21035159 | pubmed:author | pubmed-author:FangYuanY | lld:pubmed |
| pubmed-article:21035159 | pubmed:author | pubmed-author:CameronCheryl... | lld:pubmed |
| pubmed-article:21035159 | pubmed:author | pubmed-author:CameronMark... | lld:pubmed |
| pubmed-article:21035159 | pubmed:author | pubmed-author:KelvinDavid... | lld:pubmed |
| pubmed-article:21035159 | pubmed:author | pubmed-author:XuLuolingL | lld:pubmed |
| pubmed-article:21035159 | pubmed:author | pubmed-author:RanLongsiL | lld:pubmed |
| pubmed-article:21035159 | pubmed:author | pubmed-author:DaneshAliA | lld:pubmed |
| pubmed-article:21035159 | pubmed:author | pubmed-author:LeónAlberto... | lld:pubmed |
| pubmed-article:21035159 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21035159 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21035159 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:21035159 | pubmed:volume | 409 | lld:pubmed |
| pubmed-article:21035159 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21035159 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21035159 | pubmed:pagination | 102-12 | lld:pubmed |
| pubmed-article:21035159 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:21035159 | pubmed:meshHeading | pubmed-meshheading:21035159... | lld:pubmed |
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| pubmed-article:21035159 | pubmed:meshHeading | pubmed-meshheading:21035159... | lld:pubmed |
| pubmed-article:21035159 | pubmed:meshHeading | pubmed-meshheading:21035159... | lld:pubmed |
| pubmed-article:21035159 | pubmed:meshHeading | pubmed-meshheading:21035159... | lld:pubmed |
| pubmed-article:21035159 | pubmed:meshHeading | pubmed-meshheading:21035159... | lld:pubmed |
| pubmed-article:21035159 | pubmed:meshHeading | pubmed-meshheading:21035159... | lld:pubmed |
| pubmed-article:21035159 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21035159 | pubmed:articleTitle | Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation. | lld:pubmed |
| pubmed-article:21035159 | pubmed:affiliation | Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada. | lld:pubmed |
| pubmed-article:21035159 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21035159 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21035159 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
