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rdf:type |
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lifeskim:mentions |
umls-concept:C0015859,
umls-concept:C0017262,
umls-concept:C0206750,
umls-concept:C0439851,
umls-concept:C0441471,
umls-concept:C0871261,
umls-concept:C1175743,
umls-concept:C1552596,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1947931,
umls-concept:C1948023,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
2010-11-29
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU835483,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU835484,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU835487,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU835488,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU835489,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU835493,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU835985,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU835986,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU835987,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU835988,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU835989,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU835990,
http://linkedlifedata.com/resource/pubmed/xref/GEO/GSE22581
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pubmed:abstractText |
Type I interferons (IFNs) are essential to the clearance of viral diseases, however, a clear distinction between genes upregulated by direct virus-cell interactions and genes upregulated by secondary IFN production has not been made. Here, we investigated differential gene regulation in ferrets upon subcutaneous administration of IFN-?2b and during SARS-CoV infection. In vivo experiments revealed that IFN-?2b causes STAT1 phosphorylation and upregulation of abundant IFN response genes (IRGs), chemokine receptors, and other genes that participate in phagocytosis and leukocyte transendothelial migration. During infection with SARS-CoV not only a variety of IRGs were upregulated, but also a significantly broader range of genes involved in cell migration and inflammation. This work allowed dissection of several molecular signatures present during SARS-CoV which are part of a robust IFN antiviral response. These signatures can be useful markers to evaluate the status of IFN responses during a viral infection and specific features of different viruses.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1096-0341
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pubmed:author |
pubmed-author:CameronCheryl MCM,
pubmed-author:CameronMark JMJ,
pubmed-author:ChenHonglinH,
pubmed-author:DaneshAliA,
pubmed-author:DevoeGG,
pubmed-author:FangYuanY,
pubmed-author:GuanYiY,
pubmed-author:JonssonColleen BCB,
pubmed-author:KelvinDavid JDJ,
pubmed-author:LeónAlberto JAJ,
pubmed-author:RanLongsiL,
pubmed-author:RoweThomasT,
pubmed-author:XuLuolingL
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
409
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
102-12
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21035159-Animals,
pubmed-meshheading:21035159-Disease Models, Animal,
pubmed-meshheading:21035159-Ferrets,
pubmed-meshheading:21035159-Gene Expression Profiling,
pubmed-meshheading:21035159-Gene Expression Regulation,
pubmed-meshheading:21035159-Humans,
pubmed-meshheading:21035159-Interferon-alpha,
pubmed-meshheading:21035159-Male,
pubmed-meshheading:21035159-Molecular Sequence Data,
pubmed-meshheading:21035159-Proteins,
pubmed-meshheading:21035159-Recombinant Proteins,
pubmed-meshheading:21035159-SARS Virus,
pubmed-meshheading:21035159-STAT1 Transcription Factor,
pubmed-meshheading:21035159-Sequence Analysis, DNA,
pubmed-meshheading:21035159-Severe Acute Respiratory Syndrome,
pubmed-meshheading:21035159-Up-Regulation
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pubmed:year |
2011
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pubmed:articleTitle |
Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation.
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pubmed:affiliation |
Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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