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rdf:type |
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lifeskim:mentions |
umls-concept:C0028351,
umls-concept:C0028631,
umls-concept:C0031640,
umls-concept:C0033268,
umls-concept:C0036628,
umls-concept:C0040300,
umls-concept:C0086418,
umls-concept:C0205263,
umls-concept:C0243077,
umls-concept:C0332157,
umls-concept:C0442805,
umls-concept:C1140999
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pubmed:issue |
6
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pubmed:dateCreated |
2010-12-6
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pubmed:abstractText |
To investigate further the role of phosphodiesterase (PDE) isoenzymes in the control of human seminal vesicle (SV) smooth muscle contractility, we examined the functional responses of isolated SV tissue to various PDE inhibitors. It has been suggested that the application of inhibitors of the PDE type 5 may facilitate SV smooth muscle relaxation and, subsequently, retard ejaculatory response.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-(3-Butoxy-4-methoxybenzyl)-2-imida...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Forskolin,
http://linkedlifedata.com/resource/pubmed/chemical/Milrinone,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroprusside,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Purines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Rolipram,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfones,
http://linkedlifedata.com/resource/pubmed/chemical/sildenafil
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1527-9995
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1518.e1-6
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pubmed:meshHeading |
pubmed-meshheading:20970829-4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,
pubmed-meshheading:20970829-Aged,
pubmed-meshheading:20970829-Cyclic AMP,
pubmed-meshheading:20970829-Cyclic GMP,
pubmed-meshheading:20970829-Drug Evaluation, Preclinical,
pubmed-meshheading:20970829-Ejaculation,
pubmed-meshheading:20970829-Forskolin,
pubmed-meshheading:20970829-Humans,
pubmed-meshheading:20970829-Male,
pubmed-meshheading:20970829-Milrinone,
pubmed-meshheading:20970829-Muscle Relaxation,
pubmed-meshheading:20970829-Nitroprusside,
pubmed-meshheading:20970829-Norepinephrine,
pubmed-meshheading:20970829-Phosphodiesterase Inhibitors,
pubmed-meshheading:20970829-Piperazines,
pubmed-meshheading:20970829-Purines,
pubmed-meshheading:20970829-Receptors, Adrenergic, alpha,
pubmed-meshheading:20970829-Rolipram,
pubmed-meshheading:20970829-Seminal Vesicles,
pubmed-meshheading:20970829-Sulfones
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pubmed:year |
2010
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pubmed:articleTitle |
Exposure of human seminal vesicle tissue to phosphodiesterase (PDE) inhibitors antagonizes the contraction induced by norepinephrine and increases production of cyclic nucleotides.
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pubmed:affiliation |
University of Indonesia School of Medicine, Cipto Mangunkusumo Hospital, Department of Urology, Jakarta, Indonesia.
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pubmed:publicationType |
Journal Article,
In Vitro
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