Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-1-31
pubmed:abstractText
A western lifestyle, characterised by low rates of energy expenditure and a high-energy diet rich in animal protein, saturated fats and refined carbohydrates, is associated with high incidence of prostate cancer in men. A high-energy nutritional status results in insulin/IGF signalling in cells, which in turn stimulates synthesis of fatty acids. We investigated whether the genetic variability of the genes belonging to the fatty acid synthesis pathway is related to prostate cancer risk in 815 prostate cancer cases and 1266 controls from the European Prospective Investigation on Cancer (EPIC). Using a tagging approach and selecting 252 SNPs in 22 genes, we covered all the common genetic variation of this pathway. None of the SNPs reached statistical significance after adjusting for multiple comparisons. Common SNPs in the fatty acid synthase pathway are not major contributors to prostate cancer risk.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1879-0852
pubmed:author
pubmed-author:AllenNaomi ENE, pubmed-author:ArdanazEvaE, pubmed-author:BamiaChristinaC, pubmed-author:Bas Bueno-de-MesquitaHH, pubmed-author:BoeingHeinerH, pubmed-author:CampaDanieleD, pubmed-author:CanzianFedericoF, pubmed-author:ChajesVeroniqueV, pubmed-author:Chang-ClaudeJennyJ, pubmed-author:ChirlaqueMaria-DoloresMD, pubmed-author:DahmChristina CCC, pubmed-author:DostalLucieL, pubmed-author:HüsingAnikaA, pubmed-author:JohanssonMattiasM, pubmed-author:KaaksRudolfR, pubmed-author:KhawKay-TeeKT, pubmed-author:KrögerJanineJ, pubmed-author:LarrañagaNereaN, pubmed-author:NaskaAndronikiA, pubmed-author:NoratTeresaT, pubmed-author:OvervadKimK, pubmed-author:PérezMaria José SánchezMJ, pubmed-author:PalliDomenicoD, pubmed-author:RiboliElioE, pubmed-author:RinaldiSabinaS, pubmed-author:RodríguezLaudinaL, pubmed-author:RomieuIsabelleI, pubmed-author:RoswallNinaN, pubmed-author:SacerdoteCarlottaC, pubmed-author:SalaNúriaN, pubmed-author:SiddiqAfshanA, pubmed-author:SieriSabinaS, pubmed-author:StattinPärP, pubmed-author:TjønnelandAnneA, pubmed-author:TravisRuth CRC, pubmed-author:TrichopoulouAntoniaA, pubmed-author:TuminoRosarioR, pubmed-author:WarehamNickN, pubmed-author:van KranenHenk JHJ
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
420-7
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).
pubmed:affiliation
German Cancer Research Center, DKFZ, Heidelberg, Germany.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Multicenter Study