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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-11-10
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pubmed:abstractText |
The development of targeted therapies has created a pressing clinical need for molecular characterisation of cancers. In this retrospective study, high-resolution melting analysis (HRMA) was validated and implemented for screening of 164 colorectal cancer (CRC) patients to detect KRAS hot-spot mutations and to evaluate its prognostic value. Direct sequencing was used to confirm and characterise HRMA results.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1532-1827
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
9
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1627-36
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pubmed:dateRevised |
2011-11-9
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pubmed:meshHeading |
pubmed-meshheading:20959826-Cell Line, Tumor,
pubmed-meshheading:20959826-Colonic Neoplasms,
pubmed-meshheading:20959826-Colorectal Neoplasms,
pubmed-meshheading:20959826-DNA, Neoplasm,
pubmed-meshheading:20959826-DNA Primers,
pubmed-meshheading:20959826-Genetic Variation,
pubmed-meshheading:20959826-Humans,
pubmed-meshheading:20959826-Mass Screening,
pubmed-meshheading:20959826-Mutation,
pubmed-meshheading:20959826-Nucleic Acid Denaturation,
pubmed-meshheading:20959826-Polymerase Chain Reaction,
pubmed-meshheading:20959826-Prognosis,
pubmed-meshheading:20959826-Proto-Oncogene Proteins,
pubmed-meshheading:20959826-Rectal Neoplasms,
pubmed-meshheading:20959826-Regression Analysis,
pubmed-meshheading:20959826-Survival Analysis,
pubmed-meshheading:20959826-ras Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
KRAS mutation detection and prognostic potential in sporadic colorectal cancer using high-resolution melting analysis.
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pubmed:affiliation |
Laboratory of Cancer Research and Clinical Oncology, Department of Medical Oncology, University of Antwerp/Antwerp University Hospital, Wilrijk 2610, Belgium. vanessa.deschoolmeester@ua.ac.be
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pubmed:publicationType |
Journal Article
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