Source:http://linkedlifedata.com/resource/pubmed/id/20953905
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2011-4-11
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| pubmed:abstractText |
The infiltrative duct carcinoma (IDC) is the most common malignant breast cancer in females and genetic factors appear to play a significant role in the susceptibility of IDC. The LFA-1 is a crucial co-stimulatory molecule in immune system and may affect the development of breast IDC. In order to clarify the association of LFA-1 polymorphisms with IDC, a case-control study was conducted in women from Heilongjiang Province, Northeast of China. We scrutinized four genetic polymorphisms in LFA-1 gene, which may influence the activity and function of LFA-1. Our research subjects consist of 537 cases with IDC and 577 age-matched healthy controls. Genotypes were determined by PCR-RFLP. Data were analyzed using the ?(2) test by SPSS 13.0 and Haploview 4.1 softwares. The association between LFA-1 polymorphisms and the clinical features of IDC was analyzed. In rs2230433, the frequency of GG genotype and G allele was lower in cases than in controls (P = 0.0316 and 0.0480). And rs2230433, CG genotype was higher in cases (P = 0.0397). In rs8058823, the frequency of AA genotype and A allele was lower in cases than in controls (P = 0.00000418 and 0.00000267). And rs8058823, AG genotype was higher in cases (P = 0.00000747). The frequency of haplotype CCGA was lower in patients. Significant association was shown between the four SNPs of LFA-1 gene and estrogen receptor (ER), progesterone receptor (PR), C-erbB-2, and P53 statuses. In addition, no association was found between LFA-1 gene polymorphisms and tumor size, and neither was it between LFA-1 gene polymorphisms and lymph node metastasis. Our results primarily suggested that LFA-1 gene polymorphisms may predict the sporadic breast IDC risk and prognosis factors in Chinese Han women in Heilongjiang Province.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Function-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1573-7217
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
127
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
265-71
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| pubmed:meshHeading |
pubmed-meshheading:20953905-Adult,
pubmed-meshheading:20953905-Aged,
pubmed-meshheading:20953905-Alleles,
pubmed-meshheading:20953905-Breast Neoplasms,
pubmed-meshheading:20953905-Carcinoma, Ductal, Breast,
pubmed-meshheading:20953905-China,
pubmed-meshheading:20953905-Female,
pubmed-meshheading:20953905-Gene Frequency,
pubmed-meshheading:20953905-Genetic Predisposition to Disease,
pubmed-meshheading:20953905-Genotype,
pubmed-meshheading:20953905-Humans,
pubmed-meshheading:20953905-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:20953905-Middle Aged,
pubmed-meshheading:20953905-Polymorphism, Single Nucleotide,
pubmed-meshheading:20953905-Receptor, erbB-2,
pubmed-meshheading:20953905-Receptors, Estrogen,
pubmed-meshheading:20953905-Receptors, Progesterone,
pubmed-meshheading:20953905-Tumor Suppressor Protein p53,
pubmed-meshheading:20953905-Young Adult
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| pubmed:year |
2011
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| pubmed:articleTitle |
LFA-1 gene polymorphisms are associated with the sporadic infiltrative duct breast carcinoma in Chinese Han women of Heilongjiang Province.
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| pubmed:affiliation |
Department of Immunology, Harbin Medical University, Harbin 150081, China. zhenkun_fu@yahoo.com.cn
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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