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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2010-11-16
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pubmed:abstractText |
The insulin-like growth factor 1 (IGF1) signaling pathway is an important growth-regulatory pathway, which plays a crucial role in colorectal cancer (CRC) proliferation, differentiation, migration, angiogenesis, and apoptosis. Previous studies showed that hyperactivation of the IGF1 receptor (IGF1R) may result in resistance to anti-epidermal growth factor receptor-targeted treatment. We tested whether germline variations within the IGF1 pathway are associated with clinical outcome in wild-type (wt) KRAS drug-refractory metastatic CRC (mCRC) patients who were treated with cetuximab monotherapy (IMC-0144).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:BohanesPierreP,
pubmed-author:GergerArminA,
pubmed-author:LangerChristianeC,
pubmed-author:LenzHeinz-JosefHJ,
pubmed-author:MauroDavid JDJ,
pubmed-author:PohlAlexandraA,
pubmed-author:RowinskyEric KEK,
pubmed-author:WilsonPeter MPM,
pubmed-author:WinderThomasT,
pubmed-author:YanNingN,
pubmed-author:YangDongyunD,
pubmed-author:ZhangWuW
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5591-602
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pubmed:meshHeading |
pubmed-meshheading:20935157-Aged,
pubmed-meshheading:20935157-Antibodies, Monoclonal,
pubmed-meshheading:20935157-Antineoplastic Agents,
pubmed-meshheading:20935157-Colorectal Neoplasms,
pubmed-meshheading:20935157-Genetic Testing,
pubmed-meshheading:20935157-Germ-Line Mutation,
pubmed-meshheading:20935157-Humans,
pubmed-meshheading:20935157-Insulin-Like Growth Factor I,
pubmed-meshheading:20935157-Middle Aged,
pubmed-meshheading:20935157-Multivariate Analysis,
pubmed-meshheading:20935157-Polymorphism, Single Nucleotide,
pubmed-meshheading:20935157-Proto-Oncogene Proteins,
pubmed-meshheading:20935157-Signal Transduction,
pubmed-meshheading:20935157-ras Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
Germline polymorphisms in genes involved in the IGF1 pathway predict efficacy of cetuximab in wild-type KRAS mCRC patients.
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pubmed:affiliation |
Division of Medical Oncology University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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