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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017645,
umls-concept:C0031678,
umls-concept:C0162371,
umls-concept:C0442805,
umls-concept:C0600432,
umls-concept:C0882849,
umls-concept:C1335071,
umls-concept:C1441547,
umls-concept:C1442905,
umls-concept:C1824809
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pubmed:dateCreated |
2010-10-25
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pubmed:abstractText |
A potential strategy for treatment of sickle cell disease (SCD) and ?-thalassemia in adults is reactivation of the ?- and ?-globin genes in the adult. We aimed to identify trans-activators of ?- and ?-globin expression and provide new candidate targets for effective treatment of sickle cell disease (SCD) and ?-thalassemia through activation of ?- and ?-globin genes in adults.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2121
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
75
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pubmed:meshHeading |
pubmed-meshheading:20932329-Adult,
pubmed-meshheading:20932329-Anemia, Sickle Cell,
pubmed-meshheading:20932329-Antigens, CD34,
pubmed-meshheading:20932329-Erythropoiesis,
pubmed-meshheading:20932329-Fetal Blood,
pubmed-meshheading:20932329-Gene Therapy,
pubmed-meshheading:20932329-Humans,
pubmed-meshheading:20932329-K562 Cells,
pubmed-meshheading:20932329-Phosphoprotein Phosphatases,
pubmed-meshheading:20932329-RNA, Small Interfering,
pubmed-meshheading:20932329-Transcriptional Activation,
pubmed-meshheading:20932329-Transgenes,
pubmed-meshheading:20932329-Tumor Suppressor Proteins,
pubmed-meshheading:20932329-beta-Thalassemia,
pubmed-meshheading:20932329-epsilon-Globins,
pubmed-meshheading:20932329-gamma-Globins
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pubmed:year |
2010
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pubmed:articleTitle |
CTD small phosphatase like 2 (CTDSPL2) can increase ?- and ?-globin gene expression in K562 cells and CD34+ cells derived from umbilical cord blood.
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pubmed:affiliation |
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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