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pubmed-article:20877570pubmed:abstractTextType 1 diabetes (T1D) is an autoimmune disease resulting from defects in central and peripheral tolerance and characterized by T cell-mediated destruction of islet ? cells. To determine whether specific lysosomal proteases might influence the outcome of a T cell-mediated autoimmune response, we examined the functional significance of cathepsin inhibition on autoimmune T1D-prone non-obese diabetic (NOD) mice.lld:pubmed
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pubmed-article:20877570pubmed:articleTitleCathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity.lld:pubmed
pubmed-article:20877570pubmed:affiliationDepartment of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.lld:pubmed
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