|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0039194,
umls-concept:C0054871,
umls-concept:C0085358,
umls-concept:C0205734,
umls-concept:C0301625,
umls-concept:C0441655,
umls-concept:C0591833,
umls-concept:C1292733,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2010-9-29
|
|
pubmed:abstractText |
Type 1 diabetes (T1D) is an autoimmune disease resulting from defects in central and peripheral tolerance and characterized by T cell-mediated destruction of islet ? cells. To determine whether specific lysosomal proteases might influence the outcome of a T cell-mediated autoimmune response, we examined the functional significance of cathepsin inhibition on autoimmune T1D-prone non-obese diabetic (NOD) mice.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1932-6203
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
5
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
e12894
|
|
pubmed:meshHeading |
pubmed-meshheading:20877570-Animals,
pubmed-meshheading:20877570-Autoimmunity,
pubmed-meshheading:20877570-CD8-Positive T-Lymphocytes,
pubmed-meshheading:20877570-Cathepsin L,
pubmed-meshheading:20877570-Diabetes Mellitus, Type 1,
pubmed-meshheading:20877570-Disease Models, Animal,
pubmed-meshheading:20877570-Down-Regulation,
pubmed-meshheading:20877570-Female,
pubmed-meshheading:20877570-Humans,
pubmed-meshheading:20877570-Mice,
pubmed-meshheading:20877570-Mice, Inbred NOD
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity.
|
|
pubmed:affiliation |
Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
