20871666

Source:http://linkedlifedata.com/resource/pubmed/id/20871666

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0013138, umls-concept:C0015392, umls-concept:C0026336, umls-concept:C0031437, umls-concept:C0332161, umls-concept:C0949664, umls-concept:C1555707, umls-concept:C1705851, umls-concept:C2752151, umls-concept:C2828366
pubmed:dateCreated	2010-9-27
pubmed:abstractText	Drosophila models of tauopathies have been developed by transgenically overexpressing the disease-associated forms of tau. In this paper we report for the first time that a recently developed Grape-Seed Polyphenolic Extract (GSPE) improves the eye phenotype of a Drosophila eye model of R406W tau. GSPE-mediated improvements in this distinct in vivo neurodegeneration model for protein misfolding/aggregation suggest that GSPE may have therapeutic value in disorders involving aberrant protein aggregation.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101525141
pubmed:status	PubMed-not-MEDLINE
pubmed:issn	2090-0252
pubmed:author	pubmed-author:ConleyLindsay MLM, pubmed-author:FivecoatHayley CHC, pubmed-author:FriedmanLaurenL, pubmed-author:HoLapL, pubmed-author:PasinettiGiulio MGM, pubmed-author:PflegerCathie MCM, pubmed-author:VittorinoRoselleR, pubmed-author:WangJunJ
pubmed:issnType	Electronic
pubmed:volume	2010
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:year	2010
pubmed:articleTitle	Grape-seed polyphenolic extract improves the eye phenotype in a Drosophila model of tauopathy.
pubmed:affiliation	Department of Oncological Sciences, Mount Sinai School of Medicine, One Gustave L. Levy Place, NY 10029, USA.
pubmed:publicationType	Journal Article