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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2010-9-16
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pubmed:abstractText |
Malignant melanoma is the deadliest form of skin cancer and is refractory to conventional chemotherapy and radiotherapy. Therefore alternative approaches to treat this disease, such as immunotherapy, are needed. Melanoma vaccine design has mainly focused on targeting CD8+ T cells. Activation of effector CD8+ T cells has been achieved in patients, but provided limited clinical benefit, due to immune-escape mechanisms established by advanced tumors. We have previously shown that alphavirus-based virus-like replicon particles (VRP) simultaneously activate strong cellular and humoral immunity against the weakly immunogenic melanoma differentiation antigen (MDA) tyrosinase. Here we further investigate the antitumor effect and the immune mechanisms of VRP encoding different MDAs.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:dateRevised |
2011-10-12
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pubmed:meshHeading |
pubmed-meshheading:20844763-Alphavirus,
pubmed-meshheading:20844763-Animals,
pubmed-meshheading:20844763-CD8-Positive T-Lymphocytes,
pubmed-meshheading:20844763-Cancer Vaccines,
pubmed-meshheading:20844763-Cell Line, Tumor,
pubmed-meshheading:20844763-Female,
pubmed-meshheading:20844763-Gene Expression,
pubmed-meshheading:20844763-Genetic Vectors,
pubmed-meshheading:20844763-Humans,
pubmed-meshheading:20844763-Immunity, Cellular,
pubmed-meshheading:20844763-Immunity, Humoral,
pubmed-meshheading:20844763-Immunotherapy,
pubmed-meshheading:20844763-Intramolecular Oxidoreductases,
pubmed-meshheading:20844763-Melanoma,
pubmed-meshheading:20844763-Mice,
pubmed-meshheading:20844763-Mice, Inbred C57BL,
pubmed-meshheading:20844763-Mice, Knockout,
pubmed-meshheading:20844763-Replicon
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pubmed:year |
2010
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pubmed:articleTitle |
Alphavirus replicon particles expressing TRP-2 provide potent therapeutic effect on melanoma through activation of humoral and cellular immunity.
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pubmed:affiliation |
Swim Across America Laboratory, Immunology Program, Sloan-Kettering Institute, New York, New York, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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