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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-7-12
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pubmed:abstractText |
Ischemia-reperfusion injury (IRI) is responsible for primary liver dysfunction and failure after transplantation. The mitochondrial pathway appears to be involved in liver ischemia-reperfusion injury. Mitochondrial ATP-sensitive K (mitoK(ATP)) channels play a central role in protecting the heart from injury in ischemic preconditioning. The selective mitoK(ATP) channel agonist diazoxide potently reduced mitochondrial injury by preventing cytochrome c loss from the intermembrane space. Therefore, this study sought to determine whether diazoxide can attenuate ischemia-reperfusion injury induced by orthotopic liver transplantation (OLT) in mice. Furthermore, it was found that up-regulation of the Bcl-2 gene is a mechanism of diazoxide cytoprotection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1095-8673
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
169
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e155-66
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pubmed:meshHeading |
pubmed-meshheading:20828743-Animals,
pubmed-meshheading:20828743-Apoptosis,
pubmed-meshheading:20828743-Cytochromes c,
pubmed-meshheading:20828743-Cytosol,
pubmed-meshheading:20828743-Diazoxide,
pubmed-meshheading:20828743-Liver,
pubmed-meshheading:20828743-Liver Transplantation,
pubmed-meshheading:20828743-Male,
pubmed-meshheading:20828743-Mice,
pubmed-meshheading:20828743-Mice, Inbred BALB C,
pubmed-meshheading:20828743-Mitochondria, Liver,
pubmed-meshheading:20828743-Models, Animal,
pubmed-meshheading:20828743-Potassium Channels,
pubmed-meshheading:20828743-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:20828743-RNA, Small Interfering,
pubmed-meshheading:20828743-Reperfusion Injury,
pubmed-meshheading:20828743-Signal Transduction,
pubmed-meshheading:20828743-Transplantation, Homologous,
pubmed-meshheading:20828743-Up-Regulation
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pubmed:year |
2011
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pubmed:articleTitle |
Diazoxide suppresses hepatic ischemia/reperfusion injury after mouse liver transplantation by a BCL-2-dependent mechanism.
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pubmed:affiliation |
Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, PR China.
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pubmed:publicationType |
Journal Article
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