rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-12-1
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pubmed:abstractText |
Deficiency of ?(1) -antitrypsin (?(1) AT) may be a determinant of susceptibility to Wegener's granulomatosis (WG). Several previous, mainly small, case-control studies have shown that 5-27% of patients with WG carried the ?(1) AT deficiency Z allele. It is not clear whether the S allele, the other major ?(1) AT deficiency variant, is associated with WG. This study investigated the relationship of the ?(1) AT deficiency Z and S alleles with the risk of developing WG in a large cohort.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/K24 AR002224-05,
http://linkedlifedata.com/resource/pubmed/grant/K24-AR-02224,
http://linkedlifedata.com/resource/pubmed/grant/K24-HL-004456,
http://linkedlifedata.com/resource/pubmed/grant/P60 AR047785-10,
http://linkedlifedata.com/resource/pubmed/grant/P60-AR-047785,
http://linkedlifedata.com/resource/pubmed/grant/R01 AR047799-04,
http://linkedlifedata.com/resource/pubmed/grant/R01-AR-047799,
http://linkedlifedata.com/resource/pubmed/grant/U54 AR057319-06,
http://linkedlifedata.com/resource/pubmed/grant/U54 RR019497-01,
http://linkedlifedata.com/resource/pubmed/grant/U54 RR019497-05,
http://linkedlifedata.com/resource/pubmed/grant/U54-RR-019497
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1529-0131
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pubmed:author |
pubmed-author:BrantlyMark LML,
pubmed-author:DellaripaPaul FPF,
pubmed-author:EdbergJeffrey CJC,
pubmed-author:HoffmanGary SGS,
pubmed-author:MahrAlfred DAD,
pubmed-author:MerkelPeter APA,
pubmed-author:RouhaniFarshid NFN,
pubmed-author:SeoPhilipP,
pubmed-author:SpecksUlrichU,
pubmed-author:SpieraRobert FRF,
pubmed-author:St ClairE WilliamEW,
pubmed-author:StoneJohn HJH
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pubmed:copyrightInfo |
Copyright © 2010 by the American College of Rheumatology.
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pubmed:issnType |
Electronic
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3760-7
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20827781-Adult,
pubmed-meshheading:20827781-Aged,
pubmed-meshheading:20827781-Alleles,
pubmed-meshheading:20827781-Case-Control Studies,
pubmed-meshheading:20827781-European Continental Ancestry Group,
pubmed-meshheading:20827781-Female,
pubmed-meshheading:20827781-Gene Frequency,
pubmed-meshheading:20827781-Genetic Predisposition to Disease,
pubmed-meshheading:20827781-Genotype,
pubmed-meshheading:20827781-Humans,
pubmed-meshheading:20827781-Male,
pubmed-meshheading:20827781-Middle Aged,
pubmed-meshheading:20827781-Risk Factors,
pubmed-meshheading:20827781-Wegener Granulomatosis,
pubmed-meshheading:20827781-alpha 1-Antitrypsin
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pubmed:year |
2010
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pubmed:articleTitle |
Alpha?-antitrypsin deficiency-related alleles Z and S and the risk of Wegener's granulomatosis.
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pubmed:affiliation |
Boston University School of Medicine, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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